Beck J Benjamin, Killops Kato L, Kang Taegon, Sivanandan Kulandaivelu, Bayles Andrea, Mackay Michael E, Wooley Karen L, Hawker Craig J
Materials Research Laboratory University of California Santa Barbara, CA 93106-5121.
Macromolecules. 2009 Jun 9;42(15):5629-5635. doi: 10.1021/ma900899v.
A new synthetic approach to the preparation of intramolecularly collapsed nanoparticles under mild, room temperature conditions has been developed from commercially available vinyl monomers. Reaction of isocyanate functionalized linear copolymers with a diamine in dilute solution leads to the efficient formation of nanoparticles where the diameter of the nanoparticle can be varied by controlling both the molecular weight and mole percentage of isocyanate repeat units. Physical properties for the intramolecularly collapsed nanoparticles were fully consistent with a three-dimensional structure and analysis of the collapse reaction revealed that approximately 75% of the isocyanate groups along the backbone underwent crosslinking with 25% being available for further reaction with mono-functional amines. This stepwise consumption of the isocyanates allows the chemical and physical properties of the nanoparticles to be further tuned and significantly opens up the range of nanoparticles that can be prepared using this mild and highly efficient chemistry.
一种在温和的室温条件下从市售乙烯基单体制备分子内塌陷纳米颗粒的新合成方法已经开发出来。异氰酸酯官能化的线性共聚物与二胺在稀溶液中的反应导致纳米颗粒的有效形成，其中纳米颗粒的直径可以通过控制异氰酸酯重复单元的分子量和摩尔百分比来改变。分子内塌陷纳米颗粒的物理性质与三维结构完全一致，对塌陷反应的分析表明，主链上约75%的异氰酸酯基团发生了交联，25%可用于与单官能胺进一步反应。异氰酸酯的这种逐步消耗使得纳米颗粒的化学和物理性质能够进一步调整，并显著拓宽了使用这种温和且高效的化学方法可制备的纳米颗粒范围。
