Blazquez-Martín Agustín, Verde-Sesto Ester, Moreno Angel J, Arbe Arantxa, Colmenero Juan, Pomposo José A
Centro de Física de Materiales (CSIC, UPV/EHU) and Materials Physics Center MPC, Paseo Manuel de Lardizabal 5, E-20018 San Sebastián, Spain.
Donostia International Physics Center (DIPC), Paseo Manuel de Lardizabal 4, E-20018 San Sebastián, Spain.
Polymers (Basel). 2021 Jan 18;13(2):293. doi: 10.3390/polym13020293.
The folding of certain proteins (e.g., enzymes) into perfectly defined 3D conformations via multi-orthogonal interactions is critical to their function. Concerning synthetic polymers chains, the "folding" of individual polymer chains at high dilution via intra-chain interactions leads to so-called single-chain nanoparticles (SCNPs). This review article describes the advances carried out in recent years in the folding of single polymer chains into discrete SCNPs via multi-orthogonal interactions using different reactive chemical species where intra-chain bonding only occurs between groups of the same species. First, we summarize results from computer simulations of multi-orthogonally folded SCNPs. Next, we comprehensively review multi-orthogonally folded SCNPs synthesized via either non-covalent bonds or covalent interactions. Finally, we conclude by summarizing recent research about multi-orthogonally folded SCNPs prepared through both reversible (dynamic) and permanent bonds.
某些蛋白质（如酶）通过多重正交相互作用折叠成完美定义的三维构象对其功能至关重要。对于合成聚合物链而言，单个聚合物链在高稀释度下通过链内相互作用进行“折叠”会形成所谓的单链纳米颗粒（SCNP）。这篇综述文章描述了近年来在利用不同反应性化学物种通过多重正交相互作用将单个聚合物链折叠成离散的SCNP方面所取得的进展，其中链内键合仅发生在相同物种的基团之间。首先，我们总结了多正交折叠SCNP的计算机模拟结果。接下来，我们全面综述了通过非共价键或共价相互作用合成的多正交折叠SCNP。最后，我们通过总结近期关于通过可逆（动态）键和永久键制备的多正交折叠SCNP的研究来得出结论。
