Chongqing University, China.
Adv Mater. 2010 Oct 1;22(37):4146-50. doi: 10.1002/adma.201000854.
Drug-loadingmesoporous silica nanoparticles that serve as a nanoreservoir-type drug-delivery system are successfully attached to titanium substrates via the layer-by-layer assembly technique (see scheme). The obtained structure demonstrates great potential for regulating the biological behaviors of osteoblasts/ steoclasts in order to maintain bone homeostasis. The approach we present here may have wide applications in implant technology, tissue engineering, and regenerative medicine.
通过层层组装技术，成功地将作为纳米储库型药物输送系统的载药介孔硅纳米粒子附着在钛基底上（见方案）。所获得的结构在调节成骨细胞/破骨细胞的生物学行为以维持骨内稳态方面显示出巨大的潜力。我们在这里提出的方法可能在植入技术、组织工程和再生医学中有广泛的应用。
