Zhao Pengkun, Liu Hongyu, Deng Hongbing, Xiao Ling, Qin Caiqin, Du Yumin, Shi Xiaowen
School of Resource and Environmental Science and Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430079, China.
Hubei Co-Innovation Center for Utilization of Biomass Waste, Hubei Engineering University, Xiaogan 432000, China.
Colloids Surf B Biointerfaces. 2014 Nov 1;123:657-63. doi: 10.1016/j.colsurfb.2014.10.013. Epub 2014 Oct 13.
In this study, the complex pH and electro responsive system made of chitosan hydrogel with embedded mesoporous silica nanoparticles (MSNs) was evaluated as a tunable drug release system. As a model drug, ibuprofen (IB) was used; its adsorption in MSNs was evidenced by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and thermogravimetric analysis (TG). In order to prepare the complex drug release system, the loaded particles IB-MSNs were dispersed in chitosan solution and then the complex IB-MSNs/chitosan film of 2mm thickness was deposited as a hydrogel on the titanium electrode. The codeposition of components was performed under a negative biasing of the titanium electrode at -0.75 mA/cm2 current density during 30 min. The IB release from the IB-MSNs/chitosan hydrogel film was studied as dependent on pH of the release media and electrical conditions applied to the titanium plate. When incubating the complex hydrogel film in buffers with different pH, the IB release followed a near zero-order profile, though its kinetics varied. Compared to the spontaneous IB release from the hydrogel in 0.9% NaCl solution (at 0 V), the application of negative biases to the coated titanium plate had profound effluences on the release behavior. The release was retarded when -1.0 V was applied, but a faster kinetics was observed at -5.0 V. These results imply that a rapid, mild and facile electrical process for covering titanium implants by complex IB-MSNs/chitosan hydrogel films can be used for controlled drug delivery applications.
在本研究中，由嵌入介孔二氧化硅纳米颗粒（MSNs）的壳聚糖水凝胶制成的复合pH和电响应系统被评估为一种可调谐药物释放系统。使用布洛芬（IB）作为模型药物；通过傅里叶变换红外光谱（FT-IR）、扫描电子显微镜（SEM）和热重分析（TG）证明了其在MSNs中的吸附。为了制备复合药物释放系统，将负载颗粒IB-MSNs分散在壳聚糖溶液中，然后将厚度为2mm的复合IB-MSNs/壳聚糖膜作为水凝胶沉积在钛电极上。在-0.75 mA/cm2电流密度下，在钛电极的负偏压下进行30分钟的组分共沉积。研究了IB从IB-MSNs/壳聚糖水凝胶膜中的释放与释放介质的pH值以及施加到钛板上的电条件的关系。当将复合水凝胶膜在不同pH值的缓冲液中孵育时，IB的释放遵循接近零级的曲线，尽管其动力学有所不同。与在0.9% NaCl溶液（0 V）中从水凝胶中自发释放IB相比，对涂覆的钛板施加负偏压对释放行为有深远影响。施加-1.0 V时释放受到抑制，但在-5.0 V时观察到更快的动力学。这些结果表明，通过复合IB-MSNs/壳聚糖水凝胶膜覆盖钛植入物的快速、温和且简便的电过程可用于可控药物递送应用。
