Greggi Stefano, Losito Simona, Pisano Carmela, Desicato Sonia, Scaffa Cono
Gynecologic Oncology, National Cancer Institute "G. Pascale," Naples, Italy.
Int Surg. 2010 Apr-Jun;95(2):120-5.
Vaginal melanoma (VM) is a rare disease comprising <1% of all melanomas among women, and about 3% of all vaginal malignancies. Patients experience a poor prognosis, showing <15% 5-year survival. The report concerns two premenopausal patients with VM treated by surgery with radical intent. The first patient presented with a large lesion also infiltrating the proximal paracolpium and the bladder. The second patient had a persistent lesion of the lower third of the vagina. However, in the absence of any evidence-based guidelines or even clear suggestions from the literature, it is reasonable to believe that an appropriate management of primary malignant VM should address the radical tumor resection with wide tumor-free surgical margins and symptom relief.
阴道黑色素瘤（VM）是一种罕见疾病，在女性所有黑色素瘤中占比不到1%，在所有阴道恶性肿瘤中约占3%。患者预后较差，5年生存率低于15%。本报告涉及两名绝经前VM患者，接受了根治性手术治疗。首例患者表现为一个大病灶，还浸润了近端阴道旁组织和膀胱。第二例患者阴道下三分之一处有持续性病灶。然而，由于缺乏任何循证指南，甚至文献中也没有明确建议，因此有理由认为，原发性恶性VM的恰当治疗应包括广泛切缘的根治性肿瘤切除及症状缓解。
