Levêque J, Meunier B, Poulain P, Burtin F, Lesimple T, Kérisit J, Giraud J R
Département d'Oncologie, CRLCC Eugène-Marquis, Rennes.
J Gynecol Obstet Biol Reprod (Paris). 1995;24(3):268-72.
Report the diagnosis and therapeutic approach in two cases of primary malignant melanoma of the vagina.
Malignant melanoma is rarely localized in the vagina, resulting from the malignant transformation of an ectopic melanocyte during menopause. The clinical diagnosis is often made in an advanced stage with a variable degree of pigmentation, usually on the anterior aspect of the vagina. Surgical exeresis should be extensive with a 1-cm safety margin. Radiotherapy may be effective as a complementary treatment for limited surgery or as first intention therapy aimed as improving local control before surgery.
Locoregional relapse occurs in 60% of the cases, emphasizing the importance of local treatment. The prognosis is unfavourable with a 23 month mean survival. Total survival at 5 years is only 17%.
报告两例原发性阴道恶性黑色素瘤的诊断及治疗方法。
恶性黑色素瘤很少局限于阴道，是由绝经期间异位黑素细胞恶变所致。临床诊断通常在晚期做出，色素沉着程度不一，通常位于阴道前壁。手术切除范围应广泛，切缘距肿瘤1厘米。放疗可作为有限手术的辅助治疗，或作为术前旨在改善局部控制的首选治疗。
60%的病例会发生局部区域复发，凸显了局部治疗的重要性。预后不佳，平均生存期为23个月。5年总生存率仅为17%。
