Eskisehir Osmangazi University Faculty of Medicine, Department of Microbiology, Division of Mycology, Eskisehir, Turkey.
Med Mycol. 2011 Feb;49(2):126-31. doi: 10.3109/13693786.2010.503195. Epub 2010 Aug 18.
We retrospectively evaluated the distribution of clinical Candida spp. isolated over a 5-year period in our hospital relative to year, specimen types, hospital departments and their antifungal susceptibility patterns. Overall 3,756 Candida spp. were recovered from 10,857 specimens. In vitro antifungal susceptibility tests were conducted with 2,068 isolates against amphotericin B, fluconazole and itraconazole using the Etest method. C. albicans was isolated frequently from non-sterile body specimens while non-C. albicans Candida spp. were commonly recovered from sterile body specimens. Isolation rates of C. albicans were 83%, 61.2% and 49% in non-sterile body specimens, sterile body specimens and blood-sterile body fluids, respectively. C. krusei was an important isolate from specimens of patients in the Haematology and Bone Marrow Transplantation units and its rate of recovery increased in these departments. Amphotericin B resistance was detected in only seven C. krusei isolates, whereas 80% (n = 1,653), 76% (n = 1,572) and 99% (n = 2,061) of all isolates were susceptible to fluconazole, itraconazole and amphotericin B, respectively. In conclusion, the distribution of Candida species was variable among hospital departments and among body sites. These results may be useful in predicting potential fungal pathogens and the choice of antifungal treatment.
我们回顾性评估了 5 年来我院分离的临床念珠菌属的分布情况，包括年份、标本类型、医院科室及其抗真菌药敏模式。共从 10857 份标本中分离出 3756 株念珠菌属。采用 Etest 法对 2068 株分离株进行了两性霉素 B、氟康唑和伊曲康唑的体外抗真菌药敏试验。白色念珠菌常从非无菌体标本中分离，而非白色念珠菌念珠菌属常从无菌体标本中分离。非无菌体标本、无菌体标本和血无菌体液中分离出的白色念珠菌的分离率分别为 83%、61.2%和 49%。克柔念珠菌是血液科和骨髓移植病房患者标本中的重要分离株，其在这些科室的检出率有所增加。仅在 7 株克柔念珠菌中检测到两性霉素 B 耐药，而 80%（n=1653）、76%（n=1572）和 99%（n=2061）的所有分离株对氟康唑、伊曲康唑和两性霉素 B 的敏感性分别为 80%、76%和 99%。总之，念珠菌属的分布在医院科室和不同的体部位之间存在差异。这些结果有助于预测潜在的真菌病原体和抗真菌治疗的选择。
