Levin Aviad, Loyter Abraham, Bukrinsky Michael
Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Biochim Biophys Acta. 2011 Sep;1813(9):1646-53. doi: 10.1016/j.bbamcr.2010.07.010. Epub 2010 Aug 16.
Nuclear import is a critical step in the life cycle of HIV-1. During the early (preintegration) stages of infection, HIV-1 has to transport its preintegration complex into the nucleus for integration into the host cell chromatin, while at the later (postintegration) stages viral regulatory proteins Tat and Rev need to get into the nucleus to stimulate transcription and regulate splicing and nuclear export of subgenomic and genomic RNAs. Given such important role of nuclear import in HIV-1 life cycle, this step presents an attractive target for antiviral therapeutic intervention. In this review, we describe the current state of our understanding of the interactions regulating nuclear import of the HIV-1 preintegration complex and describe current approaches to inhibit it. This article is part of a Special Issue entitled: Regulation of Signaling and Cellular Fate through Modulation of Nuclear Protein Import.
核输入是HIV-1生命周期中的关键步骤。在感染的早期（整合前）阶段，HIV-1必须将其整合前复合物转运到细胞核中，以便整合到宿主细胞染色质中，而在后期（整合后）阶段，病毒调节蛋白Tat和Rev需要进入细胞核以刺激转录，并调节亚基因组和基因组RNA的剪接及核输出。鉴于核输入在HIV-1生命周期中具有如此重要的作用，这一步骤成为抗病毒治疗干预的一个有吸引力的靶点。在本综述中，我们描述了目前对调节HIV-1整合前复合物核输入的相互作用的理解现状，并介绍了当前抑制该过程的方法。本文是名为：通过调节核蛋白输入来调控信号传导和细胞命运的特刊的一部分。
