School of Behavioral and Brain Sciences, Center for BrainHealth, The University of Texas at Dallas, Dallas, TX, United States.
J Neurol Sci. 2010 Oct 15;297(1-2):1-5. doi: 10.1016/j.jns.2010.07.021. Epub 2010 Aug 16.
Poor performance on tasks requiring response inhibition has been observed among chronically ill veterans of the 1991 Persian Gulf War. Semantic difficulties have also been reported. We collected event-related potential (ERP) and behavioral data from 25 Gulf War veterans who complained of cognitive difficulties and from 23 matched controls, who were deployed but not symptomatic, while they performed a GO-NOGO task that required both a semantic decision and inhibitory processing. A significantly greater false-alarm rate among the ill veterans was accompanied in the ERP data by significantly reduced amplitude in the NOGO P3, consistent with previous ERP studies of other patient groups that have shown poor inhibitory response performance. This supports the contention that the ill veterans' deficit lies more in inhibiting than in detecting task-related differences in the stimuli.
在需要抑制反应的任务中，1991 年波斯湾战争的慢性疾病退伍军人表现不佳。也有报道称存在语义困难。我们从 25 名抱怨认知困难的海湾战争退伍军人和 23 名匹配的对照组中收集了事件相关电位（ERP）和行为数据，这些对照组在部署但没有症状时执行了一个需要语义决策和抑制处理的 GO-NOGO 任务。在 ERP 数据中，患病退伍军人的假警报率显著增加，同时在 NOGO P3 中的振幅显著降低，这与其他患者群体的先前 ERP 研究一致，这些研究表明抑制反应表现不佳。这支持了这样的论点，即患病退伍军人的缺陷更多地在于抑制而不是检测刺激中与任务相关的差异。
