性别和膳食脂肪摄入量对大鼠心脏磷脂和三酰基甘油脂肪酸组成的影响。
Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart.
机构信息
Institute of Human Nutrition, University of Southampton School of Medicine, Institute of Developmental Sciences Building, MP887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 2010 Oct-Dec;83(4-6):219-23. doi: 10.1016/j.plefa.2010.07.006. Epub 2010 Aug 16.
Variations in the fatty acid composition of lipids in the heart alter its function and susceptibility to ischaemic injury. We investigated the effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart. Rats were fed either 40 or 100g/kg fat (9:1 lard:soybean oil) from weaning until day 105. There were significant interactive effects of sex and fat intake on the proportions of fatty acids in heart phospholipids, dependent on phospholipid classes. 20:4n-6, but not 22:6n-3, was higher in phospholipids in females than males fed a low, but not a high, fat diet. There was no effect of sex on the composition of triacylglycerol. These findings suggest that sex is an important factor in determining the incorporation of dietary fatty acids into cardiac lipids. This may have implications for sex differences in susceptibility to heart disease.
脂肪酸组成的变化在心脏的脂质改变其功能和易感性缺血性损伤。我们研究了性别和饮食脂肪摄入对脂肪酸组成的磷脂和三酰甘油在大鼠心脏。大鼠从断奶后分别给予 40 或 100 克/公斤脂肪（9:1 猪油：大豆油）直到第 105 天。有显著的性别和脂肪摄入量的相互作用对脂肪酸的比例在心脏磷脂，取决于磷脂的类别。20:4n-6，但不是 22:6n-3，在磷脂中的女性比男性喂养低，但不是高脂肪饮食。性别对三酰甘油的组成没有影响。这些发现表明，性别是一个重要因素，决定了膳食脂肪酸的纳入心脏脂质。这可能对性别差异易感性心脏病。
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