Department of Communication Sciences and Disorders, University of South Carolina, Columbia, South Carolina 29208, USA.
J Neurosci. 2010 Aug 18;30(33):11057-61. doi: 10.1523/JNEUROSCI.1120-10.2010.
Patients with left hemisphere damage and concomitant aphasia usually have difficulty repeating others' speech. Although impaired speech repetition, the primary symptom of conduction aphasia, has been associated with involvement of the left arcuate fasciculus, its specific lesion correlate remains elusive. This research examined speech repetition among 45 stroke patients who underwent aphasia testing and MRI examination. Based on lesion-behavior mapping, the primary structural damage most closely associated with impaired speech repetition was found in the posterior portion of the left arcuate fasciculus. However, perfusion-weighted MRI revealed that tissue dysfunction, in the form of either frank damage or hypoperfusion, to the left inferior parietal lobe, rather than the underlying white matter, was associated with impaired speech repetition. This latter result suggests that integrity of the left inferior parietal lobe is important for speech repetition and, as importantly, highlights the importance of examining cerebral perfusion for the purpose of lesion-behavior mapping in acute stroke.
患有左半球损伤和伴随的失语症的患者通常难以重复他人的言语。虽然言语重复受损是传导性失语症的主要症状，但与左侧弓状束的参与有关，但其特定的病变相关性仍然难以捉摸。这项研究检查了 45 名中风患者的言语重复，这些患者接受了失语症测试和 MRI 检查。基于病变-行为映射，与言语重复受损最密切相关的主要结构损伤位于左侧弓状束的后部。然而，灌注加权 MRI 显示，左侧下顶叶的组织功能障碍（无论是明显损伤还是灌注不足），而不是潜在的白质，与言语重复受损有关。后一种结果表明，左侧下顶叶的完整性对于言语重复很重要，同样重要的是，它突出了为急性中风的病变-行为映射目的检查脑灌注的重要性。
