评价血管内皮生长因子在糖尿病视网膜病变中的作用。

Evaluation of the role of vascular endothelial growth factor in diabetic retinopathy.

机构信息

Department of Ophthalmology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

出版信息

Ophthalmic Res. 2011;45(2):87-91. doi: 10.1159/000317062. Epub 2010 Aug 19.

DOI:10.1159/000317062

PMID:20720438

Abstract

PURPOSE

The study is aiming at investigating the correlation between vascular endothelial growth factor (VEGF) as an angiogenic factor and diabetic retinopathy in type 2 diabetic patients and the effect of panretinal coagulation and glycemic control on VEGF.

METHODS

The study included 30 patients of type 2 diabetes, 10 of them did not suffer from any of the vascular complications of type 2 diabetes mellitus (group 1), 10 patients had nonproliferative diabetic retinopathy (group 2), 10 patients had proliferative diabetic retinopathy (PDR) (group 3) and (group 4), as well as 10 healthy subjects that served as control group. All participants were subjected to complete clinical examination including ophthalmic and medical examination, laboratory investigations comprising complete blood count, liver function test, serum creatinine, 24-hour urinary albumin excretion, lipid profile, fasting and 2-hour postprandial blood glucose, HbA(1C) and serum VEGF.

RESULTS

The study reported a highly significant increase in the serum VEGF in the diabetic patients compared to the control group (p < 0.001), and there was also a highly significant increase in the serum VEGF in the patients with PDR versus nonproliferative diabetic retinopathy (40.55 ± 8.28 vs. 20.3 ± 2.45, p < 0.001). There was a reduction in the serum VEGF in a group of diabetic patients with poor glycemic control when their diabetic state corrected through 4 months of follow-up was highly significant (17.29 ± 1.61 before vs. 9.39 ± 0.82 after control p < 0.001) as well as the reduction in the serum VEGF which was observed in a group of patients with PDR when proper panretinal photocoagulation (PRP) was applied to their retinae with 4 months of follow-up (40.55 ± 8.28 before vs. 21.15 ± 1.76 after PRP, p < 0.001).

CONCLUSION

Serum VEGF is significantly increased in diabetic patients, especially those with PDR, and this elevation of VEGF was reduced in uncontrolled diabetic patients with proper gycemic control, and in patients with PDR with proper PRP, indicating that VEGF is an angiogenic factor that reflects the degree of neovascularization in diabetic complications.

摘要

目的

本研究旨在探讨血管内皮生长因子（VEGF）作为一种血管生成因子与 2 型糖尿病患者糖尿病视网膜病变的相关性，以及全视网膜光凝和血糖控制对 VEGF 的影响。

方法

本研究纳入了 30 例 2 型糖尿病患者，其中 10 例无 2 型糖尿病血管并发症（第 1 组），10 例非增殖性糖尿病视网膜病变（第 2 组），10 例增殖性糖尿病视网膜病变（PDR）（第 3 组）和第 4 组），以及 10 名健康受试者作为对照组。所有参与者均接受全面的临床检查，包括眼科和医学检查、实验室检查包括血常规、肝功能检查、血清肌酐、24 小时尿白蛋白排泄、血脂谱、空腹和餐后 2 小时血糖、HbA（1C）和血清 VEGF。

结果

研究报告称，与对照组相比，糖尿病患者的血清 VEGF 显著升高（p < 0.001），且 PDR 患者的血清 VEGF 也显著升高与非增殖性糖尿病视网膜病变患者相比（40.55 ± 8.28 vs. 20.3 ± 2.45，p < 0.001）。在一组血糖控制不佳的糖尿病患者中，当他们的糖尿病状态在 4 个月的随访中得到纠正时，血清 VEGF 显著降低（17.29 ± 1.61 与控制前相比，9.39 ± 0.82 控制后，p < 0.001），以及在一组接受适当全视网膜光凝（PRP）的 PDR 患者中观察到的血清 VEGF 降低4 个月随访（40.55 ± 8.28 与 PRP 前相比，21.15 ± 1.76 与 PRP 后，p < 0.001）。