蒲丹参超微粉对 2 型糖尿病大鼠视网膜神经细胞凋亡的保护作用。

Protective effects of Purendan superfine powder on retinal neuron apoptosis in a rat model of type 2 diabetes mellitus.

机构信息

Department of Ophthalmology, Chengde Medical College Affiliated Hospital, Chengde 067000, Hebei Province, China.

出版信息

Neural Regen Res. 2012 Jan 25;7(3):202-6. doi: 10.3969/j.issn.1673-5374.2012.03.008.

DOI:10.3969/j.issn.1673-5374.2012.03.008

PMID:25767500

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4353115/

Abstract

This study sought to investigate the effects of Purendan superfine powder comprised of Momordica charantia, Radix Ginseng, and Radix Salviae Miltiorrhiae on neuronal apoptosis and expression of bcl-2, bax, and caspase-3, which are retinal apoptosis-associated factors in rats with diabetes mellitus induced by continuous intraperitoneal injection of streptozotocin. The results showed that Purendan superfine powder could upregulate the expression of bcl-2 protein and mRNA, and downregulate the expression of bax and caspase-3 in the retina of diabetes mellitus rats. In addition, Purendan superfine powder was shown to reduce the number of apoptotic neurons. Our experimental findings indicate that Purendan superfine powder can inhibit neuronal apoptosis in the retina of diabetes mellitus rats and has protective effects on diabetic retinopathy.

摘要

本研究旨在探讨苦瓜、人参、丹参组成的 Purendan 超细粉对链脲佐菌素诱导的糖尿病大鼠视网膜神经细胞凋亡及凋亡相关因子 bcl-2、bax、caspase-3 表达的影响。结果表明，Purendan 超细粉可上调糖尿病大鼠视网膜组织中 bcl-2 蛋白和 mRNA 的表达，下调 bax 和 caspase-3 的表达，减少凋亡神经元的数量。实验结果表明，Purendan 超细粉可抑制糖尿病大鼠视网膜神经细胞凋亡，对糖尿病视网膜病变有保护作用。