Department of Digestive Tract Diseases, Medical University of Łódź, Łódź, Poland.
Pancreatology. 2010;10(4):477-82. doi: 10.1159/000276986. Epub 2010 Aug 19.
Resistin and visfatin, hormones produced by adipose tissue, have pro-inflammatory potential; however, their role in acute pancreatitis (AP) has been investigated only rarely.
The study group comprised 32 patients with alcoholic AP and 30 controls. In all cases AP was classified as C according to Balthazar's CT score and as severe according to Ranson's criteria. The serum level of visfatin, resistin, and interleukin(IL)-8 immunoassays were measured by ELISA on admission and on the third and fifth day of hospitalization.
On the admission day serum resistin and IL-8 concentrations in AP patients were significantly higher than in controls and they further increased on the third and fifth day of hospitalization. On the admission day serum visfatin levels in AP patients were significantly higher than in controls and further increased on the third day of hospitalization. On the fifth day the levels decreased; however, they were still higher than on admission. The correlation between visfatin and resistin as well as between C-reactive protein and visfatin, resistin and IL-8 levels has been found.
In the course of AP, visfatin and resistin levels increase in parallel with C-reactive protein. We speculate that those parameters may provide an additional tool for the prognosis and monitoring of AP. and IAP.
抵抗素和内脂素是脂肪组织产生的具有促炎潜能的激素，但其在急性胰腺炎（AP）中的作用尚未得到充分研究。
研究组包括 32 例酒精性 AP 患者和 30 例对照组。根据 Balthazar CT 评分，所有病例均被分类为 C 型；根据 Ranson 标准，所有病例均被分类为重症胰腺炎。入院时及住院第 3、5 天采用 ELISA 法检测血清内脂素、抵抗素和白细胞介素（IL）-8 水平。
AP 患者入院时血清抵抗素和 IL-8 浓度显著高于对照组，且在住院第 3、5 天进一步升高。AP 患者入院时血清内脂素水平显著高于对照组，且在住院第 3 天进一步升高。第 5 天内脂素水平下降，但仍高于入院时。还发现了内脂素与抵抗素之间以及 C 反应蛋白与内脂素、抵抗素和 IL-8 水平之间的相关性。
在 AP 病程中，内脂素和抵抗素水平与 C 反应蛋白平行升高。我们推测这些参数可能为 AP 和 IAP 的预后和监测提供额外的工具。
