一组埃及肥胖糖尿病患者和非糖尿病患者的血清内脂素、抵抗素和白细胞介素-18

Serum visfatin, resistin and IL-18 in A group of Egyptian obese diabetic and non diabetic individuals.

作者信息

Mabrouk Randa, Ghareeb Hala, Shehab Abeer, Omar Khaled, El-Kabarity Rania H, Soliman Dina Ahmed, Mohamed Nesrine A

机构信息

Immunology Unit, Clincal Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

出版信息

Egypt J Immunol. 2013;20(1):1-11.

PMID:23888552

Abstract

Resistin and visfatin have been proposed as playing a role in the pathogenesis of insulin resistance. We assessed the relationship between their serum concentrations and insulin resistance in lean, obese diabetic and obese non-diabetic. We explore their relationship with inflammatory markers and anthropometric parameters in obese patients. We measured serum resistin, visfatin levels in obese diabetic, obese nondiabetic patients and in lean subjects. The concentrations of serum resistin showed significant differences among the three groups. Higher levels of visfatin occurred in obese diabetic and non diabetic compared to lean subjects. Higher levels for HOMA-IR occurred in obese diabetic and non diabetic compared to lean subjects. Resistin correlated positively with insulin, HOMA-IR and with hs-CRP in obese diabetic subjects. Visfatin correlated positively with insulin and HOMA-IR in obese diabetic and non-diabetic subjects. Resistin might be involved in the pathogenesis of diabetes. Additionally, IL-18 might be a predictor of insulin resistance.

摘要

抵抗素和内脂素被认为在胰岛素抵抗的发病机制中发挥作用。我们评估了瘦人、肥胖糖尿病患者和肥胖非糖尿病患者中它们的血清浓度与胰岛素抵抗之间的关系。我们探讨了肥胖患者中它们与炎症标志物和人体测量参数的关系。我们测量了肥胖糖尿病患者、肥胖非糖尿病患者和瘦人受试者的血清抵抗素、内脂素水平。血清抵抗素浓度在三组之间存在显著差异。与瘦人受试者相比，肥胖糖尿病患者和非糖尿病患者的内脂素水平更高。与瘦人受试者相比，肥胖糖尿病患者和非糖尿病患者的HOMA-IR水平更高。在肥胖糖尿病患者中，抵抗素与胰岛素、HOMA-IR以及hs-CRP呈正相关。在肥胖糖尿病患者和非糖尿病患者中，内脂素与胰岛素和HOMA-IR呈正相关。抵抗素可能参与糖尿病的发病机制。此外，IL-18可能是胰岛素抵抗的一个预测指标。