Department of Physiotherapy, University School of Physical Education, Poznań, Poland and Higher Vocational State School in Kalisz, Poland.
Clin Exp Rheumatol. 2010 Jan-Feb;28(1):19-24.
The increasing incidence of overweight and obesity in modern societies, and the demonstration that adipose tissue produces numerous cytokines, increases interest of investigators in the associations between adipose tissue, adipokines, CRP and insulin resistance in rheumatoid arthritis (RA) and their possible role in the pathogenesis of this disease.The purpose of the study was to investigate serum levels of visfatin, resistin, hsCRP and insulin resistance in relation to abdominal obesity in patients with RA.
Serum levels of visfatin, resistin, hsCRP and glucose metabolism parameters were measured in 46 women with RA - 22 without abdominal obesity and 24 with abdominal obesity.
Patients with RA and abdominal obesity showed significant lower visfatin levels (1.00+/-0.93 vs. 1.44+/-0.85 ng/ml; p<0.05) in comparison to those without abdominal obesity. We found significant correlations between levels of visfatin and resistin (r=0.41; p<0.01); and between resistin levels and hsCRP levels (r=0.41; p<0.01); resistin levels and leucocytes count (r=0.36; p<0.05); and resistin levels and ESR (r=0.30; p<0.05), in the whole investigated group. Visfatin as well as resistin did not correlate with anthropometric parameters or insulin resistance in whole patients with RA.
In patients with RA and abdominal obesity, in comparison to patients without abdominal obesity, significantly lower visfatin levels have been demonstrated. Resistin was associated with laboratory markers of inflammation. Positive correlation between levels of visfatin and resistin may suggest that visfatin plays a role in inflammation in RA.
现代社会超重和肥胖的发病率不断上升，而且脂肪组织产生多种细胞因子，这增加了研究人员对脂肪组织、脂肪因子、C 反应蛋白和类风湿关节炎（RA）胰岛素抵抗之间的关联的兴趣，以及它们在这种疾病发病机制中的可能作用。本研究的目的是探讨血清内脏脂肪素、抵抗素、hsCRP 和胰岛素抵抗与 RA 患者腹型肥胖的关系。
测量了 46 例 RA 患者（22 例无腹型肥胖和 24 例腹型肥胖）的血清内脏脂肪素、抵抗素、hsCRP 和葡萄糖代谢参数水平。
与无腹型肥胖的患者相比，腹型肥胖的 RA 患者的内脏脂肪素水平显著降低（1.00±0.93 与 1.44±0.85ng/ml；p<0.05）。我们发现内脏脂肪素和抵抗素水平之间存在显著相关性（r=0.41；p<0.01）；抵抗素水平与 hsCRP 水平之间（r=0.41；p<0.01）；抵抗素水平与白细胞计数之间（r=0.36；p<0.05）；抵抗素水平与 ESR 之间（r=0.30；p<0.05）在整个研究组中存在显著相关性。在整个 RA 患者中，内脏脂肪素和抵抗素与人体测量参数或胰岛素抵抗均无相关性。
与无腹型肥胖的 RA 患者相比，腹型肥胖的 RA 患者的内脏脂肪素水平显著降低。抵抗素与炎症的实验室标志物相关。内脏脂肪素和抵抗素水平之间的正相关可能表明内脏脂肪素在 RA 中的炎症中发挥作用。
