Gin H, Rigalleau V, Perlemoine C
UMR 5536 CNRS/Université de Bordeaux 2(Victor Segalen), 33000 Bordeaux, France.
J Nutr Metab. 2010;2010. doi: 10.1155/2010/340570. Epub 2009 Oct 21.
Aims. To determine the progression of body weight (BW) and body composition (BC) in patients with type 2 diabetes mellitus (T2D) on insulin therapy and the consequences on muscle strength (MS) as a reflect of free fat mass increases. Research design and methods. We analysed BC using air displacement plethysmography and MS by hand grip dynamometry in 40 T2D before and after three (M3) and six months (M6) of insulin therapy. Results. at baseline HbA1c was 9.76 +/-1.6% and BW was stable with fat mass (FM) 28 +/- 10.7 kg; and fat free mass (FFM) 52.4 +/- 11 kg; at M6, HbA1c improved to 7.56 +/- 0.8%; insulin doses tended to increase. BW gain at M6 was + 3.2 +/- 4.2 kg and with an increase of only 25% by M3; it was composed of FM, whereas FFM was unchanged. MS did not increase on insulin therapy. Conclusions. In T2D, BW gain was composed exclusively of FM with no improvement in MS.
目的。确定接受胰岛素治疗的2型糖尿病（T2D）患者的体重（BW）和身体成分（BC）变化，以及作为游离脂肪量增加反映的肌肉力量（MS）所受影响。研究设计与方法。我们采用空气置换体积描记法分析40例T2D患者在胰岛素治疗前、治疗三个月（M3）和六个月（M6）后的BC，并通过握力计测量MS。结果。基线时糖化血红蛋白（HbA1c）为9.76±1.6%，BW稳定，脂肪量（FM）为28±10.7千克，去脂体重（FFM）为52.4±11千克；在M6时，HbA1c改善至7.56±0.8%；胰岛素剂量有增加趋势。M6时BW增加了3.2±4.2千克，M3时仅增加了25%；增加的是FM，而FFM未变。胰岛素治疗期间MS未增加。结论。在T2D患者中，BW增加仅由FM构成，MS无改善。
