Laurent Sébastien, Sabot Anne-Sophie, Colle Marie-Anne, Nicolier Alexandra
Unité d'Anatomie Pathologique, UMR ENVN-INRA 703, Ecole Nationale Vétérinaire de Nantes, 44087 Nantes, France.
J Zoo Wildl Med. 2010 Mar;41(1):104-10. doi: 10.1638/2009-0119.1.
In April 2007, two newborn springboks (Antidorcas marsupialis) from a zoo of southern France were found dead. Necropsy was performed on the two animals and revealed arthrogryposis, mild facial structural abnormalities, and bilateral enlargement of the kidneys with concurrent hydronephrosis in both newborns. Histopathologically, extensive cytoplasmic vacuolation of neurons in the central nervous system, thyroid follicular epithelium, renal tubular epithelium, enterocytes, hepatocytes, and ruminal epithelial cells was the most remarkable lesion in both animals. By electron microscopy, the vacuoles were membrane bound and contained scattered membranous and granular material within a primarily electron-lucent background. Hence, a diagnosis of lysosomal storage disease was established, with gross, histological, and ultrastructural features suggestive of an inherited form of mannosidosis. This report documents the first case of lysosomal storage disease in springboks.
2007年4月，法国南部一家动物园的两只新生跳羚（南非小羚羊）被发现死亡。对这两只动物进行了尸检，发现有关节弯曲、轻度面部结构异常，且两只新生跳羚均出现双侧肾脏肿大并伴有肾积水。组织病理学检查显示，中枢神经系统、甲状腺滤泡上皮、肾小管上皮、肠上皮细胞、肝细胞和瘤胃上皮细胞中的神经元出现广泛的细胞质空泡化，这是两只动物最显著的病变。通过电子显微镜观察，这些空泡有膜包裹，在主要为电子透明的背景中含有散在的膜性和颗粒状物质。因此，确诊为溶酶体贮积病，大体、组织学和超微结构特征提示为一种遗传性甘露糖苷贮积症。本报告记录了跳羚中首例溶酶体贮积病病例。
