巴西无尾蝠（Tadarida brasiliensis）圈养群体对商用狂犬病灭活疫苗接种的反应。
Response to vaccination with a commercial inactivated rabies vaccine in a captive colony of Brazilian free-tailed bats (Tadarida brasiliensis).
作者信息
Turmelle Amy S, Allen Louise C, Schmidt-French Barbara A, Jackson Felix R, Kunz Thomas H, McCracken Gary F, Rupprecht Charles E
机构信息
Department of Ecology and Evolutionary Biology, University of Tennessee, Knoxville, Tennessee 37996, USA.
出版信息
J Zoo Wildl Med. 2010 Mar;41(1):140-3. doi: 10.1638/2008-0161.1.
A captive colony of Brazilian free-tailed bats (Tadarida brasiliensis) was vaccinated with a commercial monovalent inactivated rabies virus (RABV) vaccine (RABVAC 1). Baseline rabies virus neutralizing antibodies (VNA) and the response to vaccination were measured in 50 bats. Rabies VNA was detected in the plasma of 64% (27/42) of bats that had been vaccinated 1 yr prior, but only 19% (8/42) had levels considered adequate. Rabies VNA was detected in the plasma of 63% (5/8) of bats with no record of previous vaccination, suggesting natural RABV exposure before captivity. All bats demonstrated a VNA response by 10 days postvaccination, and baseline titer significantly predicted humoral response to vaccination. No adverse reactions to vaccination or clinical signs of RABV infection were observed in the bats during a 6-mo observation period. Annual vaccination may maintain immunity against RABV infection in captive colonies of bats. Bat, rabies virus, Tadarida brasiliensis, vaccination, virus neutralizing antibodies.
用一种商业化单价灭活狂犬病病毒（RABV）疫苗（RABVAC 1）对一群圈养的巴西无尾蝠（巴西犬吻蝠）进行了接种。在50只蝙蝠中检测了基线狂犬病病毒中和抗体（VNA）以及对疫苗接种的反应。在1年前接种过疫苗的蝙蝠中，64%（27/42）的血浆中检测到狂犬病VNA，但只有19%（8/42）的水平被认为足够。在没有先前接种记录的蝙蝠中，63%（5/8）的血浆中检测到狂犬病VNA，这表明在圈养之前蝙蝠曾自然接触过RABV。所有蝙蝠在接种疫苗后10天均表现出VNA反应，并且基线滴度显著预测了对疫苗接种的体液反应。在6个月的观察期内，未在蝙蝠中观察到对疫苗接种的不良反应或RABV感染的临床症状。每年接种疫苗可能会维持圈养蝙蝠群体对RABV感染的免疫力。蝙蝠、狂犬病病毒、巴西犬吻蝠、疫苗接种、病毒中和抗体。
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