Dennison Sophie E, Gulland Frances M D, Braselton W Emmett
The Marine Mammal Center, 1065 Fort Cronkhite, Sausalito, California 94965, USA.
J Zoo Wildl Med. 2010 Mar;41(1):144-7. doi: 10.1638/2008-0179.1.
Abstract: Plasma clearance of iohexol was evaluated in eight anesthetized California sea lions (Zalophus californianus), without evidence of renal dysfunction, to determine if the one-compartment model and the sample protocol used in dogs and cats could be applied to this species. Nonlinearity between samples in 75% (6/8) of sea lions voided those results. An additional two anesthetized sea lions were sampled at 5, 30, 45, 60, 120, 180, 240, and 360 min post iohexol injection and semi-logarithmic curves calculated. Plasma iohexol clearance values calculated by one-, two-, and noncompartment models were in poor agreement, suggesting that the standardized protocol described for dogs and cats cannot simply be applied to California sea lions, probably due to the effects of the dive reflex induced during anesthesia.
在八只无肾功能障碍迹象的麻醉加利福尼亚海狮（北海狮）中评估了碘海醇的血浆清除率，以确定用于犬猫的一室模型和采样方案是否可应用于该物种。75%（6/8）的海狮样本间存在非线性，导致这些结果无效。另外两只麻醉海狮在注射碘海醇后5、30、45、60、120、180、240和360分钟进行采样，并计算半对数曲线。由一室、二室和非房室模型计算的血浆碘海醇清除率值一致性较差，这表明描述的用于犬猫的标准化方案不能简单地应用于加利福尼亚海狮，这可能是由于麻醉期间诱导的潜水反射的影响。
