瑜伽与散步对情绪、焦虑和大脑 GABA 水平的影响：一项随机对照 MRS 研究。
Effects of yoga versus walking on mood, anxiety, and brain GABA levels: a randomized controlled MRS study.
机构信息
Division of Psychiatry, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA.
出版信息
J Altern Complement Med. 2010 Nov;16(11):1145-52. doi: 10.1089/acm.2010.0007. Epub 2010 Aug 19.
OBJECTIVES
Yoga and exercise have beneficial effects on mood and anxiety. γ-Aminobutyric acid (GABA)-ergic activity is reduced in mood and anxiety disorders. The practice of yoga postures is associated with increased brain GABA levels. This study addresses the question of whether changes in mood, anxiety, and GABA levels are specific to yoga or related to physical activity.
METHODS
Healthy subjects with no significant medical/psychiatric disorders were randomized to yoga or a metabolically matched walking intervention for 60 minutes 3 times a week for 12 weeks. Mood and anxiety scales were taken at weeks 0, 4, 8, 12, and before each magnetic resonance spectroscopy scan. Scan 1 was at baseline. Scan 2, obtained after the 12-week intervention, was followed by a 60-minute yoga or walking intervention, which was immediately followed by Scan 3.
RESULTS
The yoga subjects (n = 19) reported greater improvement in mood and greater decreases in anxiety than the walking group (n = 15). There were positive correlations between improved mood and decreased anxiety and thalamic GABA levels. The yoga group had positive correlations between changes in mood scales and changes in GABA levels.
CONCLUSIONS
The 12-week yoga intervention was associated with greater improvements in mood and anxiety than a metabolically matched walking exercise. This is the first study to demonstrate that increased thalamic GABA levels are associated with improved mood and decreased anxiety. It is also the first time that a behavioral intervention (i.e., yoga postures) has been associated with a positive correlation between acute increases in thalamic GABA levels and improvements in mood and anxiety scales. Given that pharmacologic agents that increase the activity of the GABA system are prescribed to improve mood and decrease anxiety, the reported correlations are in the expected direction. The possible role of GABA in mediating the beneficial effects of yoga on mood and anxiety warrants further study.
目的
瑜伽和运动对情绪和焦虑有有益的影响。γ-氨基丁酸（GABA）能活性在情绪和焦虑障碍中降低。瑜伽姿势的练习与大脑 GABA 水平的增加有关。本研究探讨了情绪、焦虑和 GABA 水平的变化是否是瑜伽特有的，还是与身体活动有关。
方法
没有明显医学/精神疾病的健康受试者被随机分为瑜伽组或代谢匹配的步行干预组，每周 3 次，每次 60 分钟，共 12 周。在 0、4、8、12 周和每次磁共振波谱扫描前进行情绪和焦虑量表评估。扫描 1 在基线时进行。扫描 2 在 12 周干预后进行，随后进行 60 分钟的瑜伽或步行干预，立即进行扫描 3。
结果
瑜伽组（n=19）报告的情绪改善更大，焦虑减少更多，而步行组（n=15）则没有。情绪改善与焦虑减少与丘脑 GABA 水平呈正相关。瑜伽组的情绪量表变化与 GABA 水平变化之间存在正相关。
结论
12 周的瑜伽干预与代谢匹配的步行运动相比，与情绪和焦虑的更大改善相关。这是第一项表明增加丘脑 GABA 水平与情绪改善和焦虑减少相关的研究。也是第一次表明行为干预（即瑜伽姿势）与丘脑 GABA 水平的急性增加与情绪和焦虑量表的改善之间存在正相关。鉴于增加 GABA 系统活性的药物被开处方以改善情绪和减少焦虑，报告的相关性在预期的方向上。GABA 在介导瑜伽对情绪和焦虑的有益影响中的可能作用值得进一步研究。
Zotero 插件