Baharvand M, Mortazavi A, Mortazavi H, Yaseri M
Department of Oral and Maxillofacial Medicine, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Pharmaeutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ann Med Health Sci Res. 2014 Nov;4(6):858-62. doi: 10.4103/2141-9248.144877.
Until now, several formulations of topical phenytoin have been used to promote wound healing.
This study was aimed at re-evaluating the effects of a newly formulated phenytoin mucoadhesive paste on wound healing after oral biopsy.
In a double-blind clinical trial, 35 consecutive patients with oral lichenoid or lichen planus lesions were randomized into two groups. After incisional biopsy, patients applied simple, or 1% phenytoin paste at least three times a day (after each meal), for 4 days. They were evaluated every other day for size of wound closure, severity of pain, and diameter of the inflammatory halo. This study was approved by Medical Ethics committee of Shahid Beheshti University of Medical Sciences, Tehran, Iran. Statistical analysis was performed using Mann-Whitney U test and Ordinal Logistic Regression.
Of 35 patients, 17 (10 [10/17, 59%]) men, 7 (7/17, 41%) women, mean age: 40 (4.11) were in phenytoin group, and 18 (9 [9/9, 50%]) men, 9 (9/9, 50%) women, mean age: 43.1 (5.15) were in placebo group. There were no significant differences between both study groups in terms of age and sex (male/female ratio) (P = 0.76, P = 0.88). As all biopsies were done by means of punch number 8, the incisions were of 10 mm length. After second and third appointments, it was observed that patients in the treatment group showed quicker wound closure and less pain compared to control group significantly (P < 0.05). Although not significant, patients treated with phenytoin paste had smaller inflammatory halo than controls.
Applying 1% phenytoin mucoadhesive paste on oral biopsy incisions resulted in accelerated wound healing and decrease in pain.
到目前为止，几种局部用苯妥英制剂已被用于促进伤口愈合。
本研究旨在重新评估一种新配制的苯妥英粘膜粘附糊剂对口腔活检后伤口愈合的影响。
在一项双盲临床试验中，35例连续性口腔扁平苔藓样或扁平苔藓病变患者被随机分为两组。切开活检后，患者每天至少三次（每餐饭后）涂抹单纯糊剂或1%苯妥英糊剂，持续4天。每隔一天对患者的伤口闭合大小、疼痛严重程度和炎症晕直径进行评估。本研究经伊朗德黑兰谢赫·贝赫什提医科大学医学伦理委员会批准。采用曼-惠特尼U检验和有序逻辑回归进行统计分析。
35例患者中，苯妥英组有17例（男性10例[10/17，59%]，女性7例[7/17，41%]），平均年龄40岁（4.11岁）；安慰剂组有18例（男性9例[9/9，50%]，女性9例[9/9，50%]），平均年龄43.1岁（5.15岁）。两个研究组在年龄和性别（男/女比例）方面无显著差异（P = 0.76，P = 0.88）。由于所有活检均使用8号打孔器进行，切口长度为10毫米。在第二次和第三次复诊时，观察到治疗组患者的伤口闭合速度比对照组快，疼痛程度比对照组轻，差异有统计学意义（P < 0.05）。虽然差异不显著，但使用苯妥英糊剂治疗的患者炎症晕比对照组小。
在口腔活检切口中涂抹1%苯妥英粘膜粘附糊剂可加速伤口愈合并减轻疼痛。
