Dept. of Food Science and Nutrition, Zhejiang Univ., Hangzhou, China.
J Food Sci. 2010 Aug 1;75(6):H205-11. doi: 10.1111/j.1750-3841.2010.01716.x.
Atherosclerosis and its related complications are the leading causes of death in the West and in many developed countries. This study aims to investigate the hypolipidemic effect of bamboo shoot oil (BSO) in Sprague-Dawley rats. A group of rats had induced hyperlipidemia, hypercholesterolemia, and fatty liver by being fed with a high-fat, high-cholesterol diet for 4 wk. The control group was administered 10 mL distilled water per kg body weight, while the other groups were, respectively, administered 250 mg beta-sitosterol, 250 mg BSO, 500 mg BSO, and 1000 mg BSO per kg body weight by oral gavage. The results demonstrated that BSO could significantly decrease the levels of total cholesterol, triacylglycerol, low-density lipoprotein-cholesterol, phytosterol, lipoprotein lipase, hepatic lipase, and atherogenic index in serum, and increase the levels of cholesterol in feces. It could also significantly decrease the level of relative liver weight and liver lipids. The pronounced hypolipidemic effects of BSO might be attributed to its ability to inhibit cholesterol absorption and increase cholesterol excretion. These results suggest that consuming BSO may provide benefits in managing hypercholesterolemia. Therefore, BSO may be a good candidate for development as a functional food and nutraceutical.
动脉粥样硬化及其相关并发症是西方和许多发达国家的主要死亡原因。本研究旨在探讨竹笋油（BSO）在 Sprague-Dawley 大鼠中的降血脂作用。一组大鼠通过高脂、高胆固醇饮食喂养 4 周，诱导产生高血脂、高胆固醇血症和脂肪肝。对照组给予 10 mL 蒸馏水/公斤体重，而其他组分别给予 250 mg β-谷甾醇、250 mg BSO、500 mg BSO 和 1000 mg BSO/公斤体重口服灌胃。结果表明，BSO 可显著降低血清总胆固醇、三酰甘油、低密度脂蛋白胆固醇、植物固醇、脂蛋白脂酶、肝脂酶和动脉粥样硬化指数水平，并增加粪便中胆固醇水平。它还可以显著降低相对肝重和肝脂质水平。BSO 明显的降血脂作用可能归因于其抑制胆固醇吸收和增加胆固醇排泄的能力。这些结果表明，食用 BSO 可能有益于治疗高胆固醇血症。因此，BSO 可能是开发功能性食品和营养保健品的良好候选物。
