Zhang Jiali, Liu Jingna, Li Ling, Xia Wenshui
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
Nutr Res. 2008 Jun;28(6):383-90. doi: 10.1016/j.nutres.2007.12.013.
The hypolipidemic mechanism of chitosan was investigated in male Sprague-Dawley rats. Animals were divided into 5 groups (n = 8): a normal fat control group, a high-fat control group (HF), a positive control group (CR), and 2 chitosan groups (CIS1 and CIS2). Chitosan was fed at the beginning (CIS1) and after 2 weeks (CIS2). A commercial diet with 5% (wt/wt) cellulose (HF), cholestyramine (CR), or chitosan (CIS1, CIS2) was fed for 6 weeks. Chitosan did not affect food intake but decreased body weight gain and significantly increased fecal fat and cholesterol excretion, reduced the lipid level in plasma and liver, increased liver hepatic and lipoprotein lipase activities compared with HF (P < .05), and tended to relieve the degenerated fatty liver tissue. No significant differences in all measurements were found between the CIS1 and CIS2 groups although the CIS1 rats exhibited lower lipid levels compared to those in the CIS2 group. The results suggest that chitosan reduced the absorption of dietary fat and cholesterol in vivo and could effectively improve hypercholesterolemia in rats.
在雄性斯普拉格-道利大鼠中研究了壳聚糖的降血脂机制。动物被分为5组（n = 8）：正常脂肪对照组、高脂对照组（HF）、阳性对照组（CR）和2个壳聚糖组（CIS1和CIS2）。壳聚糖在开始时（CIS1）和2周后（CIS2）喂食。用含5%（重量/重量）纤维素的商业饲料（HF）、消胆胺（CR）或壳聚糖（CIS1、CIS2）喂养6周。壳聚糖不影响食物摄入量，但降低了体重增加，并显著增加了粪便脂肪和胆固醇排泄，降低了血浆和肝脏中的脂质水平，与HF组相比增加了肝脏肝脂酶和脂蛋白脂肪酶活性（P <.05），并倾向于缓解退化的脂肪肝组织。尽管CIS1组大鼠的脂质水平低于CIS2组，但CIS1组和CIS2组之间在所有测量中均未发现显著差异。结果表明，壳聚糖在体内降低了膳食脂肪和胆固醇的吸收，并能有效改善大鼠的高胆固醇血症。
