全膝关节置换术后骨关节炎患者健康结局的评估：两年随访。
Evaluation of health outcomes in osteoarthritis patients after total knee replacement: a two-year follow-up.
机构信息
Programs for Assessment of Technology in Health, St, Joseph's Healthcare Hamilton, Hamilton, L8P 1H1, Canada.
出版信息
Health Qual Life Outcomes. 2010 Aug 19;8:87. doi: 10.1186/1477-7525-8-87.
Abstract
OBJECTIVES
To quantify the improvement in health outcomes in patients after total knee replacement (TKR).
METHODS
This was a two-year non-randomized prospective observational study in knee osteoarthritis (OA) patients undergone TKR. Patients were interviewed one week before, six months after, and two years after surgery using a standardized questionnaire including the SF-36, the Oxford Knee Score (OKS), and the Knee Society Clinical Rating Scale (KSS). A generalized estimating equation (GEE) model was used to estimate the magnitudes of the changes with and without the adjustment of age, ethnicity, BMI, and years with OA.
RESULTS
A total of 298 (at baseline), 176 (at six-months), and 111 (at two-years) eligible patients were included in the analyses. All the scores changed significantly over time, with the exception of SF-36 social functioning, vitality, and mental health. With the adjustment of covariates, the magnitude of changes in these scores was similar to those without the adjustment.
CONCLUSIONS
Both general and knee-specific physical functioning had been significantly improved after TKR, while other health domains have not been substantially improved after the surgery.
摘要
目的
定量评估全膝关节置换术（TKR）后患者的健康结果改善情况。
方法
这是一项为期两年的非随机前瞻性观察性研究，纳入了膝关节骨关节炎（OA）患者接受 TKR 治疗。患者在术前一周、术后六个月和两年时使用标准化问卷进行访谈，问卷包括 SF-36、牛津膝关节评分（OKS）和膝关节学会临床评分量表（KSS）。采用广义估计方程（GEE）模型来估计调整年龄、种族、BMI 和 OA 患病年限前后变化的幅度。
结果
共纳入 298 名（基线时）、176 名（术后六个月时）和 111 名（术后两年时）符合条件的患者进行分析。所有评分均随时间显著变化，除 SF-36 社会功能、活力和心理健康外。调整协变量后，这些评分的变化幅度与未调整时相似。
结论
TKR 后，一般和膝关节特定的躯体功能显著改善，而手术后其他健康领域并未得到实质性改善。
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