Valdés G, Vio C P, Montero J, Avendaño R
Escuela de Medicina y Facultad de Ciencias Biológicas, Pontificia Universidad Católica, Santiago, Chile.
J Hum Hypertens. 1991 Apr;5(2):91-6.
In order to eludicate possible mechanism(s) involved in the blood pressure reduction induced by potassium (K) supplementation, we studied the changes of BP and of some of its regulatory systems, including levels of urinary kallikrein (UKal)--an index of renal kallikrein production. Twenty-four untreated essential hypertensives, with a basal BP of 147/96 +/- 13/7 mmHg and normal renal function, received in crossover, double-blind, randomised fashion, 64 mmol KCl or placebo during two periods of 4 weeks each. At the 4th week of potassium supplementation systolic, diastolic and mean BPs decreased by 6.3 +/- 2 (P less than 0.01), 3.0 +/- 2 and 4.1 +/- 2 (P less than 0.05) mmHg respectively for the supine position, and 5.0 +/- 2, 4.0 +/- 2 (P less than 0.05) and 4.0 +/- 1 (P less than 0.05) mmHg for the standing position. Urinary potassium (K) increased from 55 +/- 4 to 123 +/- 6 mmol/24 hours (P less than 0.001) and UKal from 692 +/- 69 to 1052 +/- 141 mU/24 hours (P less than 0.01). Serum K rose from 3.8 +/- 0.1 mEq/l to 4.1 +/- 0.1 mmol/l (P less than 0.001) and PRA from 0.77 +/- 0.12 to 0.99 +/- 0.14 ng/ml/h (P less than 0.05). Correlations were observed between UKal and urinary K (r = 0.44, P less than 0.0001); between differences in UKal and urinary K and in UKal and urinary Na (r = 0.50, P less than 0.0005 and r = 0.48, P less than 0.001 respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
为了阐明补钾引起血压降低可能涉及的机制，我们研究了血压及其一些调节系统的变化，包括尿激肽释放酶（UKal）水平——这是肾激肽释放酶产生的一个指标。24名未经治疗的原发性高血压患者，基础血压为147/96±13/7 mmHg，肾功能正常，以交叉、双盲、随机方式，在两个为期4周的时间段内分别接受64 mmol氯化钾或安慰剂。补钾第4周时，仰卧位收缩压、舒张压和平均血压分别下降6.3±2（P<0.01）、3.0±2和4.1±2（P<0.05）mmHg，站立位分别下降5.0±2、4.0±2（P<0.05）和4.0±1（P<0.05）mmHg。尿钾从55±4增加到每24小时123±6 mmol（P<0.001），UKal从692±69增加到每24小时1052±141 mU（P<0.01）。血清钾从3.8±0.1 mEq/l升至4.1±0.1 mmol/l（P<0.001），肾素活性从0.77±0.12升至0.99±0.14 ng/ml/h（P<0.05）。观察到UKal与尿钾之间存在相关性（r = 0.44，P<0.0001）；UKal与尿钾的差异以及UKal与尿钠的差异之间存在相关性（分别为r = 0.50，P<0.
