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HPV 疫苗的第二幕:推广、竞争和强制。

HPV vaccination's second act: promotion, competition, and compulsion.

机构信息

Center forBioethics and Department of History andSociology of Science, University ofPennsylvania, Philadelphia, PA 19104, USA.

出版信息

Am J Public Health. 2010 Oct;100(10):1841-4. doi: 10.2105/AJPH.2010.193060. Epub 2010 Aug 19.

DOI:10.2105/AJPH.2010.193060
PMID:20724671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2936995/
Abstract

Developments regarding human papillomavirus (HPV) vaccines will transform HPV vaccination in the United States while simultaneously raising several new policy and ethical concerns. Policymakers, vaccine manufacturers, and the public health community must now respond to the presence of competing vaccines that are similar but distinct, particularly with respect to genital wart prevention and the benefits of vaccinating males. This work arises in the shadow of the contentious introduction of the HPV vaccine Gardasil (Merck & Co, Inc, Whitehouse Station, NJ) in 2006, particularly the opposition to efforts in many states to require the vaccine for school attendance. I review the current status of HPV vaccine policy in the United States and examine issues of public health ethics and policy central to ongoing and future HPV vaccination programs.

摘要

人乳头瘤病毒(HPV)疫苗的发展将改变美国的 HPV 疫苗接种,同时引发若干新的政策和伦理问题。政策制定者、疫苗制造商和公共卫生界现在必须应对具有相似但又不同的竞争疫苗的出现,特别是在预防生殖器疣和接种男性疫苗的益处方面。这项工作是在 2006 年有争议地引入 HPV 疫苗 Gardasil(默克公司,新泽西州怀特豪斯站)的背景下开展的,特别是在许多州反对为了上学而要求接种疫苗的努力。我回顾了美国 HPV 疫苗政策的现状,并研究了与正在进行和未来的 HPV 疫苗接种计划相关的公共卫生伦理和政策问题。

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本文引用的文献

1
The cost-effectiveness of male HPV vaccination in the United States.美国男性 HPV 疫苗接种的成本效益。
Vaccine. 2011 Oct 26;29(46):8443-50. doi: 10.1016/j.vaccine.2011.07.096. Epub 2011 Aug 2.
2
FDA licensure of quadrivalent human papillomavirus vaccine (HPV4, Gardasil) for use in males and guidance from the Advisory Committee on Immunization Practices (ACIP).美国食品药品监督管理局批准四价人乳头瘤病毒疫苗(HPV4,佳达修)用于男性,并提供免疫实践咨询委员会(ACIP)的指导。
MMWR Morb Mortal Wkly Rep. 2010 May 28;59(20):630-2.
3
FDA licensure of bivalent human papillomavirus vaccine (HPV2, Cervarix) for use in females and updated HPV vaccination recommendations from the Advisory Committee on Immunization Practices (ACIP).美国食品药品监督管理局批准二价人乳头瘤病毒疫苗(HPV2,佳达修)用于女性,并更新了免疫实践咨询委员会(ACIP)的 HPV 疫苗接种建议。
MMWR Morb Mortal Wkly Rep. 2010 May 28;59(20):626-9.
4
A decade of controversy: balancing policy with evidence in the regulation of prescription drug advertising.十年争议:在处方药广告监管中平衡政策与证据
Am J Public Health. 2010 Jan;100(1):24-32. doi: 10.2105/AJPH.2008.153767.
5
Human papillomavirus prevalence and type distribution in penile carcinoma.人乳头瘤病毒在阴茎癌中的流行率和型别分布。
J Clin Pathol. 2009 Oct;62(10):870-8. doi: 10.1136/jcp.2008.063149. Epub 2009 Aug 25.
6
Prevention of rotavirus gastroenteritis among infants and children: recommendations of the Advisory Committee on Immunization Practices (ACIP).婴幼儿轮状病毒胃肠炎的预防:免疫实践咨询委员会(ACIP)的建议
MMWR Recomm Rep. 2009 Feb 6;58(RR-2):1-25.
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Direct to confusion: lessons learned from marketing BRCA testing.直接导致混乱:从BRCA检测营销中吸取的教训。
Am J Bioeth. 2008 Jun;8(6):5-8. doi: 10.1080/15265160802248179.
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Genital warts: mountains or molehills?尖锐湿疣:小题大做还是确有其事?
Lancet Infect Dis. 2008 May;8(5):277-8. doi: 10.1016/S1473-3099(08)70079-3.
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Lessons from the failure of human papillomavirus vaccine state requirements.人乳头瘤病毒疫苗国家要求失败的教训。
Clin Pharmacol Ther. 2007 Dec;82(6):760-3. doi: 10.1038/sj.clpt.6100397. Epub 2007 Oct 31.
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Mandatory HPV vaccination: public health vs private wealth.强制性人乳头瘤病毒疫苗接种:公共卫生与私人财富
JAMA. 2007 May 2;297(17):1921-3. doi: 10.1001/jama.297.17.1921.