补体依赖性抗原转运至 B 细胞滤泡。
Complement-dependent transport of antigen into B cell follicles.
机构信息
The Immune Disease Institute and Program in Cellular and Molecular Medicine, Children's Hospital, Boston, MA 02115, USA.
出版信息
J Immunol. 2010 Sep 1;185(5):2659-64. doi: 10.4049/jimmunol.1000522.
Abstract
Since the original proposal by Fearon and Locksley (Fearon and Locksley. 1996. Science 272: 50-53) that the complement system linked innate and adaptive immunity, there has been a rapid expansion of studies on this topic. With the advance of intravital imaging, a number of recent papers revealed an additional novel pathway in which complement C3 and its receptors enhance humoral immunity through delivery of Ag to the B cell compartment. In this review, we discuss this pathway and highlight several novel exceptions recently found with a model influenza vaccine, such as mannose-binding lectin opsonization of influenza and uptake by macrophages, and the capture of virus by dendritic cells residing in the medullary compartment of peripheral lymph nodes.
摘要
自 Fearon 和 Locksley（Fearon 和 Locksley。1996. Science 272: 50-53）最初提出补体系统将先天免疫和适应性免疫联系起来以来，针对这一主题的研究迅速扩展。随着活体成像技术的进步，最近的一些论文揭示了补体 C3 及其受体通过将 Ag 递送至 B 细胞区室来增强体液免疫的另一种新途径。在这篇综述中，我们讨论了这一途径，并强调了最近在流感疫苗模型中发现的几个新的例外情况，例如流感的甘露糖结合凝集素调理作用和被巨噬细胞摄取，以及驻留在周围淋巴结髓质区室中的树突状细胞捕获病毒。
相似文献
1
Complement-dependent transport of antigen into B cell follicles.
J Immunol. 2010 Sep 1;185(5):2659-64. doi: 10.4049/jimmunol.1000522.
2
Complement-Opsonized Nano-Carriers Are Bound by Dendritic Cells (DC) via Complement Receptor (CR)3, and by B Cell Subpopulations via CR-1/2, and Affect the Activation of DC and B-1 Cells.
Int J Mol Sci. 2021 Mar 11;22(6):2869. doi: 10.3390/ijms22062869.
3
Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes.
Nat Immunol. 2010 May;11(5):427-34. doi: 10.1038/ni.1856. Epub 2010 Mar 21.
4
Adaptive immune responses are dispensable for isolated lymphoid follicle formation: antigen-naive, lymphotoxin-sufficient B lymphocytes drive the formation of mature isolated lymphoid follicles.
J Immunol. 2005 May 1;174(9):5720-8. doi: 10.4049/jimmunol.174.9.5720.
5
Cutaneous lymphocyte antigen is expressed on memory/effector B cells in the peripheral blood and monocytoid B cells in the lymphoid tissues.
Cell Immunol. 1999 Oct 10;197(1):39-45. doi: 10.1006/cimm.1999.1552.
6
Follicular dendritic cells in germinal center reactions.
Adv Exp Med Biol. 1993;329:461-5. doi: 10.1007/978-1-4615-2930-9_77.
7
8
Absence of L-selectin delays mucosal B cell responses in nonintestinal effector tissues.
J Immunol. 2002 Nov 15;169(10):5649-59. doi: 10.4049/jimmunol.169.10.5649.
9
Expression of the Grb2-related protein of the lymphoid system in B cell subsets enhances B cell antigen receptor signaling through mitogen-activated protein kinase pathways.
J Immunol. 2003 Jan 1;170(1):349-55. doi: 10.4049/jimmunol.170.1.349.
10
ILT receptors at the interface between lymphoid and myeloid cells.
Curr Top Microbiol Immunol. 2000;251:161-6. doi: 10.1007/978-3-642-57276-0_20.
引用本文的文献
1
Complement in Antibody-Mediated Rejection of the Kidney Graft: From Pathophysiology to Clinical Practice.
J Clin Med. 2025 Apr 18;14(8):2810. doi: 10.3390/jcm14082810.
2
DNA origami vaccines program antigen-focused germinal centers.
bioRxiv. 2025 Mar 1:2025.02.21.639354. doi: 10.1101/2025.02.21.639354.
3
Advances in the study of B cells in renal ischemia-reperfusion injury.
Front Immunol. 2023 Nov 1;14:1216094. doi: 10.3389/fimmu.2023.1216094. eCollection 2023.
4
Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network.
Nat Immunol. 2023 Aug;24(8):1281-1294. doi: 10.1038/s41590-023-01559-1. Epub 2023 Jul 13.
5
Complement: Functions, location and implications.
Immunology. 2023 Oct;170(2):180-192. doi: 10.1111/imm.13663. Epub 2023 May 24.
6
Complement, complosome, and complotype: A perspective.
Eur J Immunol. 2023 Dec;53(12):e2250042. doi: 10.1002/eji.202250042. Epub 2023 May 11.
7
The Complement System in Kidney Transplantation.
Cells. 2023 Mar 2;12(5):791. doi: 10.3390/cells12050791.
8
Lymphoid stromal cells - potential implications for the pathogenesis of CVID.
Front Immunol. 2023 Feb 17;14:1122905. doi: 10.3389/fimmu.2023.1122905. eCollection 2023.
9
Complement Inhibition in Kidney Transplantation: Where Are We Now?
BioDrugs. 2023 Jan;37(1):5-19. doi: 10.1007/s40259-022-00567-1. Epub 2022 Dec 13.
10
Transcriptome and proteome analysis of innate immune responses to inactivated Leptospira and bivalent Leptospira vaccines in canine 030-D cells.
Sci Rep. 2022 Aug 4;12(1):13418. doi: 10.1038/s41598-022-16457-z.
本文引用的文献
1
Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes.
Nat Immunol. 2010 May;11(5):427-34. doi: 10.1038/ni.1856. Epub 2010 Mar 21.
2
A protease-dependent mechanism for initiating T-dependent B cell responses to large particulate antigens.
J Immunol. 2010 Apr 1;184(7):3609-17. doi: 10.4049/jimmunol.1000077. Epub 2010 Mar 5.
3
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.
Nat Immunol. 2009 Dec;10(12):1283-91. doi: 10.1038/ni.1820. Epub 2009 Nov 8.
4
B-cell follicle development remodels the conduit system and allows soluble antigen delivery to follicular dendritic cells.
Blood. 2009 Dec 3;114(24):4989-97. doi: 10.1182/blood-2009-06-229567. Epub 2009 Aug 27.
5
Uncoupling CD21 and CD19 of the B-cell coreceptor.
Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14490-5. doi: 10.1073/pnas.0903477106. Epub 2009 Aug 12.
6
Mannose-binding lectin and innate immunity.
Immunol Rev. 2009 Jul;230(1):9-21. doi: 10.1111/j.1600-065X.2009.00789.x.
7
Visualizing B cell capture of cognate antigen from follicular dendritic cells.
J Exp Med. 2009 Jul 6;206(7):1485-93. doi: 10.1084/jem.20090209. Epub 2009 Jun 8.
8
Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation.
Nat Immunol. 2009 Jul;10(7):786-93. doi: 10.1038/ni.1745. Epub 2009 Jun 7.
9
Complement and natural antibody are required in the long-term memory response to influenza virus.
Vaccine. 2008 Dec 30;26 Suppl 8:I86-93. doi: 10.1016/j.vaccine.2008.11.057.
10
An overview of influenza haemagglutinin and neuraminidase.
Biologicals. 2009 Jun;37(3):177-8. doi: 10.1016/j.biologicals.2009.02.012. Epub 2009 Mar 9.
Zotero 插件