补体依赖性抗原转运至 B 细胞滤泡。
Complement-dependent transport of antigen into B cell follicles.
机构信息
The Immune Disease Institute and Program in Cellular and Molecular Medicine, Children's Hospital, Boston, MA 02115, USA.
出版信息
J Immunol. 2010 Sep 1;185(5):2659-64. doi: 10.4049/jimmunol.1000522.
Abstract
Since the original proposal by Fearon and Locksley (Fearon and Locksley. 1996. Science 272: 50-53) that the complement system linked innate and adaptive immunity, there has been a rapid expansion of studies on this topic. With the advance of intravital imaging, a number of recent papers revealed an additional novel pathway in which complement C3 and its receptors enhance humoral immunity through delivery of Ag to the B cell compartment. In this review, we discuss this pathway and highlight several novel exceptions recently found with a model influenza vaccine, such as mannose-binding lectin opsonization of influenza and uptake by macrophages, and the capture of virus by dendritic cells residing in the medullary compartment of peripheral lymph nodes.
摘要
自 Fearon 和 Locksley（Fearon 和 Locksley。1996. Science 272: 50-53）最初提出补体系统将先天免疫和适应性免疫联系起来以来，针对这一主题的研究迅速扩展。随着活体成像技术的进步，最近的一些论文揭示了补体 C3 及其受体通过将 Ag 递送至 B 细胞区室来增强体液免疫的另一种新途径。在这篇综述中，我们讨论了这一途径，并强调了最近在流感疫苗模型中发现的几个新的例外情况，例如流感的甘露糖结合凝集素调理作用和被巨噬细胞摄取，以及驻留在周围淋巴结髓质区室中的树突状细胞捕获病毒。
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