Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
Endocr J. 2010;57(10):931-8. doi: 10.1507/endocrj.k10e-175. Epub 2010 Aug 17.
Type 2 diabetes is characterized by progressive β-cell dysfunction. Family history of type 2 diabetes has been known to be associated with an increased risk for the development of the disease. However, few studies have evaluated the effects of family history of diabetes on residual β-cell function in type 2 diabetic patients. We investigated associations among family histories, clinical characteristics and plasma C-peptide levels in type 2 diabetic patients. A total of 1,350 patients with type 2 diabetes were recruited. The patients with a family history of type 2 diabetes had younger age at onset of diabetes, longer diabetes duration, higher LDL-cholesterol, and lower fasting C-peptide levels than the patients without family history. When divided according to the tertiles of diabetes duration, patients with a family history of type 2 diabetes had more decreased concentrations of fasting C-peptide as duration of diabetes increased, but patients without a family history did not. Multiple regression models were used to determine the association between fasting plasma C-peptide levels and a family history of type 2 diabetes mellitus. With adjustments for age and sex, glycated hemoglobin (HbA(1C)), fasting plasma glucose, free fatty acids, body mass index and diabetes mellitus (DM) duration, there was a significant association (P < 0.01). Our results showed that a family history of diabetes was significantly associated with the progressive decline of fasting plasma C-peptide levels in Korean type 2 diabetes mellitus.
2 型糖尿病的特征为进行性β细胞功能障碍。已知 2 型糖尿病家族史与该疾病的发病风险增加相关。然而，很少有研究评估糖尿病家族史对 2 型糖尿病患者残余β细胞功能的影响。我们研究了 2 型糖尿病患者的家族史、临床特征和血浆 C 肽水平之间的关系。共招募了 1350 例 2 型糖尿病患者。与无家族史的患者相比，有 2 型糖尿病家族史的患者发病年龄更小、糖尿病病程更长、LDL-胆固醇更高、空腹 C 肽水平更低。当根据糖尿病病程的三分位数进行分组时，随着糖尿病病程的延长，有 2 型糖尿病家族史的患者空腹 C 肽浓度下降更明显，但无家族史的患者则没有。采用多元回归模型确定空腹血浆 C 肽水平与 2 型糖尿病家族史之间的关系。在调整年龄、性别、糖化血红蛋白（HbA1C）、空腹血糖、游离脂肪酸、体重指数和糖尿病病程后，两者仍存在显著相关性（P<0.01）。我们的结果表明，糖尿病家族史与韩国 2 型糖尿病患者空腹血浆 C 肽水平的进行性下降显著相关。
