Bo S, Cavallo-Perin P, Gentile L, Repetti E, Pagano G
Department of Internal Medicine, University of Turin, Italy.
Diabet Med. 2000 Jul;17(7):538-42. doi: 10.1046/j.1464-5491.2000.00330.x.
To evaluate the roles of maternal and paternal diabetes and diabetes in relatives other than parents on the clinical characteristics in Type 2 diabetes mellitus.
A total of 2,113 Type 2 diabetic patients were recruited, and those with diabetic mothers, diabetic fathers, diabetic relatives other than parents and no known diabetic relatives, were considered separately.
The prevalence of diabetes in the mother, father and other relatives was 25.5, 6.5 and 21.2%, respectively. No difference in the clinical characteristics was found in patients with diabetes in the mother or father. Patients with parental diabetes were significantly younger, with higher LDL-cholesterol, prevalence of retinopathy and lower age at diabetes diagnosis than those without familial diabetes; on multiple logistic regression, only age (P = 0.0003), age at diabetes diagnosis (P = 0.0014) (inverse association), and LDL-cholesterol (P = 0.030) remained significantly associated with parental diabetes. Patients with diabetic relatives other than parents displayed significantly higher total and LDL-cholesterol, prevalence of retinopathy and lower age at diabetes diagnosis that those with no known diabetic relatives; on multiple logistic regression, only age at diabetes diagnosis was inversely associated with diabetes in relatives other than parents (P = 0.013).
The data do not indicate a different influence of maternal and paternal diabetes on the clinical characteristics of Type 2 diabetic patients, while there is evidence that parental diabetes brings to an earlier onset of the disease and higher LDL-cholesterol values; the presence of diabetes in relatives other than parents constituted a small risk for earlier manifestation of the disease.
评估母亲和父亲患糖尿病以及父母以外亲属患糖尿病对2型糖尿病临床特征的影响。
共招募了2113例2型糖尿病患者，并分别考虑其母亲患糖尿病、父亲患糖尿病、父母以外亲属患糖尿病以及无已知糖尿病亲属的患者。
母亲、父亲和其他亲属的糖尿病患病率分别为25.5%、6.5%和21.2%。母亲或父亲患糖尿病的患者在临床特征上未发现差异。有父母患糖尿病的患者比无家族糖尿病的患者显著年轻，低密度脂蛋白胆固醇水平更高，视网膜病变患病率更高，糖尿病诊断年龄更低；在多因素逻辑回归分析中，只有年龄（P = 0.0003）、糖尿病诊断年龄（P = 0.0014）（呈负相关）和低密度脂蛋白胆固醇（P = 0.030）与父母患糖尿病仍有显著相关性。父母以外亲属患糖尿病的患者比无已知糖尿病亲属的患者总胆固醇和低密度脂蛋白胆固醇水平显著更高，视网膜病变患病率更高，糖尿病诊断年龄更低；在多因素逻辑回归分析中，只有糖尿病诊断年龄与父母以外亲属患糖尿病呈负相关（P = 0.013）。
数据未表明母亲和父亲患糖尿病对2型糖尿病患者临床特征有不同影响，而有证据表明父母患糖尿病会使疾病发病更早且低密度脂蛋白胆固醇值更高；父母以外亲属患糖尿病是疾病较早表现的一个小风险因素。
