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大脑大静脉动脉瘤样畸形的血管内治疗。正常静脉引流对治疗策略选择的影响。

Endovascular management of vein of Galen aneurysmal malformations. Influence of the normal venous drainage on the choice of a treatment strategy.

作者信息

Pearl Monica, Gomez Juan, Gregg Lydia, Gailloud Philippe

机构信息

Division of Interventional Neuroradiology, The Johns Hopkins Hospital, Baltimore, MD, USA.

出版信息

Childs Nerv Syst. 2010 Oct;26(10):1367-79. doi: 10.1007/s00381-010-1257-0. Epub 2010 Aug 20.

Abstract

INTRODUCTION

Vein of Galen arteriovenous malformations (VGAM) are rare intracranial vascular lesions mostly involving young children. Endovascular therapy is the current standard of care. Albeit interventional techniques have greatly reduced the once dismal vital and functional prognoses previously associated with these lesions, the treatment of VGAMs remains a complex therapeutic challenge.

DISCUSSIONS

This article reviews the available endovascular options for VGAM therapy, emphasizing three points that we have identified as critical in our practice for the establishment of a treatment strategy: (1) the importance of the deep cerebral venous anatomy, in particular the existence of normal drainage through the Galenic system in spite of the VGAM; (2) the concept of treatment staging, for arterial as well as for venous interventions; and (3) the definition of a therapeutic goal that can be attained at a reasonable cost in terms of complication risks and functional outcome.

摘要

引言

大脑大静脉动静脉畸形(VGAM)是罕见的颅内血管病变,主要累及幼儿。血管内治疗是目前的标准治疗方法。尽管介入技术已大大降低了这些病变曾经相关的极差的生存和功能预后,但VGAM的治疗仍然是一项复杂的治疗挑战。

讨论

本文回顾了VGAM治疗可用的血管内治疗选择,强调了我们在实践中确定为制定治疗策略关键的三点:(1)大脑深部静脉解剖结构的重要性,特别是尽管存在VGAM,但通过大脑大静脉系统存在正常引流;(2)治疗分期的概念,包括动脉和静脉干预;(3)根据并发症风险和功能结果以合理成本可实现的治疗目标的定义。

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