Program in Neuroscience, John W. and Jean C. Boylan Center for Cellular and Molecular Physiology, Mount Desert Island Biological Laboratory, Old Bar Harbor Road, P.O. Box 35, Salisbury Cove, ME 04672, USA.
Cell Mol Life Sci. 2010 Dec;67(24):4135-69. doi: 10.1007/s00018-010-0482-8. Epub 2010 Aug 21.
Crustaceans have long been used for peptide research. For example, the process of neurosecretion was first formally demonstrated in the crustacean X-organ-sinus gland system, and the first fully characterized invertebrate neuropeptide was from a shrimp. Moreover, the crustacean stomatogastric and cardiac nervous systems have long served as models for understanding the general principles governing neural circuit functioning, including modulation by peptides. Here, we review the basic biology of crustacean neuropeptides, discuss methodologies currently driving their discovery, provide an overview of the known families, and summarize recent data on their control of physiology and behavior.
甲壳类动物长期以来一直被用于肽研究。例如，神经分泌过程首先在甲壳类动物的 X 器官-窦腺系统中得到正式证明，并且第一个完全表征的无脊椎动物神经肽来自虾。此外，甲壳类动物的口胃和心脏神经系统长期以来一直被用作理解控制神经回路功能的一般原则的模型，包括肽的调节。在这里，我们回顾了甲壳类动物神经肽的基础生物学，讨论了当前推动其发现的方法学，概述了已知家族，并总结了它们对生理和行为控制的最新数据。
