Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Cell Host Microbe. 2013 Jun 12;13(6):652-64. doi: 10.1016/j.chom.2013.05.014.
Persistent viral infections are the result of a series of connected events that culminate in diminished immunity and the inability to eliminate infection. By building our understanding of how distinct components of the immune system function both individually and collectively in productive versus abortive responses, new potential therapeutic targets can be developed to overcome immune dysfunction and thus fight persistent infections. Using lymphocytic choriomeningitis virus (LCMV) as a model of a persistent virus infection and drawing parallels to persistent human viral infections such as human immunodeficiency virus (HIV) and hepatitis C virus (HCV), we describe the cellular relationships and interactions that determine the outcome of initial infection and highlight immune targets for therapeutic intervention to prevent or treat persistent infections. Ultimately, these findings will further our understanding of the immunologic basis of persistent viral infection and likely lead to strategies to treat human viral infections.
持续性病毒感染是一系列连续事件的结果，最终导致免疫功能下降和无法消除感染。通过深入了解免疫系统的不同组成部分在产生性和中止性反应中的个体和集体作用，我们可以开发新的潜在治疗靶点，以克服免疫功能障碍，从而对抗持续性感染。我们使用淋巴细胞性脉络丛脑膜炎病毒（LCMV）作为持续性病毒感染的模型，并与持续性人类病毒感染（如人类免疫缺陷病毒（HIV）和丙型肝炎病毒（HCV））进行类比，描述了决定初始感染结果的细胞关系和相互作用，并强调了免疫治疗靶点，以预防或治疗持续性感染。最终，这些发现将加深我们对持续性病毒感染的免疫学基础的理解，并可能为治疗人类病毒感染提供策略。
