Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Br J Surg. 2010 Nov;97(11):1704-9. doi: 10.1002/bjs.7196.
National guidelines for prophylactic oophorectomy in women with colorectal cancer are lacking. The aim of this population-based cohort study was to report on the prevalence, incidence and prognosis of ovarian metastases from colorectal cancer, providing information relevant to the discussion of prophylactic oophorectomy.
All 4566 women with colorectal cancer in Stockholm County during 1995-2006 were included and followed until 2008. Prospectively collected data regarding clinical characteristics, treatment and outcome were obtained from the Regional Quality Registry.
The prevalence of ovarian metastases at the time of diagnosis of colorectal cancer was 1.1 per cent (34 of 3172) among women with colonic cancer and 0.6 per cent (8 of 1394) among those with rectal cancer (P = 0.105). After radical resection of stage I-III colorectal cancer, metachronous ovarian metastases were found during follow-up in 1.1 per cent (22 of 1971) with colonic cancer and 0.1 per cent (1 of 881) with rectal cancer (P = 0.006). Survival in patients with ovarian metastases was poor.
Ovarian metastases from colorectal cancer are uncommon.
缺乏针对结直肠癌女性预防性卵巢切除术的国家指南。本基于人群的队列研究旨在报告结直肠癌卵巢转移的患病率、发病率和预后，为预防性卵巢切除术的讨论提供相关信息。
纳入了 1995-2006 年斯德哥尔摩县所有 4566 例结直肠癌女性患者，并随访至 2008 年。从区域质量登记处获得了关于临床特征、治疗和结局的前瞻性收集数据。
在诊断结直肠癌时，结肠癌患者卵巢转移的患病率为 1.1%（34/3172），直肠癌患者为 0.6%（8/1394）（P=0.105）。在根治性切除 I-III 期结直肠癌后，在随访期间发现结肠癌患者中有 1.1%（22/1971）和直肠癌患者中有 0.1%（1/881）发生卵巢转移（P=0.006）。卵巢转移患者的生存情况较差。
结直肠癌卵巢转移并不常见。
