离体蟾蜍膀胱中体内保护剂对氧中毒缺乏保护作用。
Lack of protection against oxygen toxicity by in vivo protective agents in the isolated toad bladder.
作者信息
Miller J H, Mendoza S A
出版信息
Aviat Space Environ Med. 1978 May;49(5):665-70.
Agents which protect against the development of oxygen toxicity in vivo were tested in an in vitro system, the isolated urinary bladder of the toad Bufo marinus. None of the agents protected against the inhibition of sodium transport across the bladder by hyperbaric oxygen exposure. Two protective agents, disulfiram and diethyldithiocarbamic acid, significantly increased the rate and extent of sodium transport inhibition by 5 ATA of oxygen, either when added in vitro or given in vivo. It was concluded that oxygen toxicity protective agents may have a nonspecific action in vivo.
在体外系统（即海蟾蜍Bufo marinus的离体膀胱）中测试了可防止体内氧中毒发生的药剂。没有一种药剂能防止高压氧暴露对膀胱钠转运的抑制作用。两种保护剂，即双硫仑和二乙基二硫代氨基甲酸盐，无论是在体外添加还是体内给药，均能显著提高5个绝对大气压氧气对钠转运抑制的速率和程度。得出的结论是，氧中毒保护剂在体内可能具有非特异性作用。
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