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增强型体外反搏(EECP)治疗难治性心绞痛(RAP):首个病例系列研究结果

Enhanced external counter pulsation (EECP) for refractory angina pectoris (RAP); results from a first case series.

作者信息

Ahmed Waqas, Akhter Naveed, Masood Ayesha

机构信息

Department of Cardiology, Shifa International Hospital, Islamabad, Pakistan.

出版信息

J Pak Med Assoc. 2010 Aug;60(8):692-4.

Abstract

Enhanced External Counterpulsation (EECP) has emerged as a promising non-invasive modality not only for patients with refractory angina pectoris (RAP) but also for patients with heart failure. To our knowledge, no published data exists in Pakistan about the benefits of EECP. We report on a case series of 16 consecutive patients undergoing EECP. All patients were either deemed not to be candidates for revascularization or had failed revascularization with RAP on optimal medical therapy. Data was collected regarding the coronary anatomy, clinical presentation, Pre and Post EECP Canadian Cardiovascular Society (CCS) class, nitrate use and 6-min walk test. Patients with severe peripheral vascular disease and arrhythmias were excluded. The mean age was 56 +/- 11.1 years. Eight patients had 3-vessel disease. 4 post-CABG with occluded grafts and the rest with variable combination of coronary disease. Seven (44%) patients had Unstable Angina and 9 (56%) had Stable Angina. The mean 6 min walk distance before EECP was 295 +/- 148.60 meters and after EECP was 360 +/- 102.12 meters (p = 0.013). The CCS class before and after EECP also showed significant improvement (p = 0.017). Sublingual nitroglycerine use also showed a positive trend after EECP. EECP was noted to be a safe and effective modality for patients with RAP with statistically significant improvement in measures of quality of life.

摘要

增强型体外反搏(EECP)已成为一种有前景的非侵入性治疗方式,不仅适用于难治性心绞痛(RAP)患者,也适用于心力衰竭患者。据我们所知,巴基斯坦尚无关于EECP益处的已发表数据。我们报告了一组连续16例接受EECP治疗的病例。所有患者要么被认为不适合进行血运重建,要么在最佳药物治疗下血运重建失败且患有RAP。收集了有关冠状动脉解剖结构、临床表现、EECP前后加拿大心血管学会(CCS)分级、硝酸酯类药物使用情况及6分钟步行试验的数据。排除了患有严重外周血管疾病和心律失常的患者。平均年龄为56±11.1岁。8例患者患有三支血管病变。4例冠状动脉旁路移植术(CABG)后移植血管闭塞,其余患者患有不同组合的冠状动脉疾病。7例(44%)患者患有不稳定型心绞痛,9例(56%)患有稳定型心绞痛。EECP前平均6分钟步行距离为295±148.60米,EECP后为360±102.12米(p = 0.013)。EECP前后的CCS分级也有显著改善(p = 0.017)。EECP后舌下含服硝酸甘油的使用也呈现出积极趋势。对于RAP患者,EECP被认为是一种安全有效的治疗方式,生活质量指标有统计学意义的改善。

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