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利多卡因与布比卡因用于牛经尾段硬膜外途径使用多端口导管进行腰旁麻醉的比较

Lignocaine versus bupivacaine for flank anaesthesia using multiport catheters via a caudal epidural approach in cattle.

作者信息

DeRossi R, Verde-Selva A B, Bertoni R A, Ruzzon R H S, Silva-Neto A B

机构信息

Department of Veterinary Medicine - Surgery and Anesthesiology, Faculty of Veterinary Medicine and Animal Science, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.

出版信息

Aust Vet J. 2010 Sep;88(9):362-7. doi: 10.1111/j.1751-0813.2010.00608.x.

DOI:10.1111/j.1751-0813.2010.00608.x
PMID:20726973
Abstract

OBJECTIVE

To determine the anaesthetic and systemic effects of dorsolumbar epidural anaesthesia using non-stylet multiport catheters via the caudal approach to administer hypertonic 5% lignocaine (HL) or hypertonic 0.5% bupivacaine (HB) to the flank in standing cattle.

MATERIALS AND METHODS

Six healthy adult cattle weighing 310-455 kg received 0.2 mg/kg HL or 0.025 mg/kg of HB; control animals received 0.9% saline solution. All drugs were injected into the dorsolumbar epidural space via a caudal approach through a non-stylet multiport catheter. Each animal received each treatment at random. Evaluations of anaesthesia, ataxia, heart rate, arterial pressures, respiratory rate and rectal temperature were obtained at 0 (basal), 5, 10, 15, 30, 45, 60, 75, and 90 min after epidural injection and then at 30-min intervals until loss of anaesthesia. All animals received a standard noxious stimulus and a 4-point scale was used to score the response. A second scale was used to score ataxia.

RESULTS

The duration of anaesthesia in the upper and lower flanks in cattle was 68 +/- 12 and 110 +/- 15 min (mean +/- SD) after dorsolumbar epidural HL or HB, respectively. Both hypertonic local anaesthetics produced a mild ataxia. The systemic changes were within acceptable limits in these clinically healthy cattle.

CONCLUSION

In standing cattle the dorsolumbar epidural injection of hypertonic lignocaine provided faster onset of anaesthesia and fewer cardiovascular effects, but had a shorter duration of anaesthesia than hypertonic bupivacaine.

摘要

目的

通过尾侧入路使用无芯多端口导管向站立牛的胁腹注射高渗5%利多卡因(HL)或高渗0.5%布比卡因(HB),以确定腰背部硬膜外麻醉的麻醉效果和全身影响。

材料与方法

6头体重310 - 455 kg的健康成年牛分别接受0.2 mg/kg HL或0.025 mg/kg HB;对照动物接受0.9%盐溶液。所有药物均通过尾侧入路经无芯多端口导管注入腰背部硬膜外腔。每头动物随机接受每种处理。在硬膜外注射后0(基础)、5、10、15、30、45、60、75和90分钟,然后每隔30分钟进行一次麻醉、共济失调、心率、动脉压、呼吸频率和直肠温度的评估,直至麻醉消失。所有动物均接受标准有害刺激,并使用4分制对反应进行评分。使用第二种评分制对共济失调进行评分。

结果

腰背部硬膜外注射HL或HB后,牛上、下胁腹的麻醉持续时间分别为68±12分钟和110±15分钟(平均值±标准差)。两种高渗局部麻醉药均引起轻度共济失调。在这些临床健康的牛中,全身变化在可接受范围内。

结论

在站立牛中,腰背部硬膜外注射高渗利多卡因麻醉起效更快,心血管影响更小,但麻醉持续时间比高渗布比卡因短。

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