Department of Veterinary Medicine, Surgery and Anesthesiology, Faculty of Veterinary Medicine and Animal Science, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
Res Vet Sci. 2012 Apr;92(2):278-82. doi: 10.1016/j.rvsc.2010.11.006. Epub 2010 Dec 16.
The aim of this study was to evaluate 3 doses of levobupivacaine (LB) epidurally administered in sheep. Six adult male 24-36 month-old sheep received levobupivacaine at 3 doses, LB05 (0.05 mg/kg), LB15 (0.15 mg/kg), and LB25 (0.25mg/kg), and saline solution into the lumbosacral epidural space. Heart rate, arterial blood pressure (systolic, diastolic, and mean), respiratory rate, rectal, and skin temperature, local anesthesia, and ataxia were determined before treatment and at predetermined intervals. The duration of local anesthesia was 30±5 min, 145±27 min, and 290±18 min for LB05, LB15, and LB25, respectively (P<0.05). Ataxia determined for LB05, LB15, or LB25 was similar to the anesthetic times. There was an increase in heart rate and reduction in arterial pressure in LB25 (P<0.05), whereas LB05 or LB15 did not affect these parameters. Lumbosacral epidural levobupivacaine is an appropriate choice for local anesthesia in sheep.
本研究旨在评估绵羊硬膜外给予 3 种剂量左布比卡因（LB）的效果。6 只 24-36 月龄成年雄性绵羊接受 LB05（0.05mg/kg）、LB15（0.15mg/kg）和 LB25（0.25mg/kg）及生理盐水硬膜外腔注射。治疗前及预定间隔时间测定心率、动脉血压（收缩压、舒张压和平均压）、呼吸频率、直肠和皮肤温度、局部麻醉和共济失调。LB05、LB15 和 LB25 的局部麻醉持续时间分别为 30±5min、145±27min 和 290±18min（P<0.05）。LB05、LB15 或 LB25 测定的共济失调与麻醉时间相似。LB25 时心率增加，动脉压降低（P<0.05），而 LB05 或 LB15 不影响这些参数。腰骶硬膜外左布比卡因是绵羊局部麻醉的合适选择。
