Clarke R S, Lyons S M
Acta Anaesthesiol Scand. 1977;21(4):282-92. doi: 10.1111/j.1399-6576.1977.tb01221.x.
Diazepam and flunitrazepam were compared in equipotent doses as induction agents for premedicated patients having cardiac surgery. Both drugs caused a significant fall in arterial blood pressure, a rise in Paco2 and a fall in Pao2. There was no significant difference between the two drugs in onset time of anaesthesia, cardiovascular or respiratory depression, or quality of induction. There was also no significant difference from induction with thiopentone in these respects. Diazepam, over a 0.2 to 0.6 mg/kg range of doses showed no difference in toxicity, although induction was clinically smoother with the higher dose.
在接受心脏手术的麻醉前用药患者中，比较了地西泮和氟硝西泮作为诱导剂的等效剂量。两种药物均导致动脉血压显著下降、动脉血二氧化碳分压（Paco2）升高和动脉血氧分压（Pao2）下降。两种药物在麻醉起效时间、心血管或呼吸抑制或诱导质量方面无显著差异。在这些方面，与硫喷妥钠诱导也无显著差异。地西泮在0.2至0.6mg/kg剂量范围内，毒性无差异，尽管高剂量时诱导在临床上更平稳。
