Jenko Pražnikar Zala, Mohorko Nina, Gmajner Dejan, Kenig Saša, Petelin Ana
Faculty of Health Sciences, University of Primorska, 6310 Izola, Slovenia.
Biostile Ltd., 6223 Komen, Slovenia.
Foods. 2023 May 24;12(11):2122. doi: 10.3390/foods12112122.
Obesity and its associated complications require various lifestyle changes and treatment options. Dietary supplements are considered an attractive alternative to traditional therapy, mainly because they are accessible to the general population. The aim of this study was to investigate the additive effects of a combination of energy restriction (ER) and four dietary supplements on changes in the anthropometric and biochemical parameters in 100 overweight or obese participants who were randomly assigned one of the dietary fibre supplements containing different dietary fibres or a placebo for 8 weeks. The results confirmed that fibre supplements plus ER significantly ( < 0.01) reduced the body weight, body mass index (BMI), fat mass, and visceral fat and ameliorated the lipid profile and inflammation at 4 and 8 weeks after the start of the study, while in the placebo group, significant differences in some parameters were observed only after 8 weeks of ER. A fibre supplement containing glucomannan, inulin, psyllium, and apple fibre was the most effective at reducing the BMI, body weight, and CRP ( = 0.018 for BMI and body weight and = 0.034 for CRP compared to placebo at the end of the intervention). Overall, the results suggest that dietary fibre supplements in combination with ER may have additional effects on weight loss and the metabolic profile. Therefore, taking dietary fibre supplements may be a feasible approach to improve weight and metabolic health in obese and overweight individuals.
肥胖及其相关并发症需要多种生活方式的改变和治疗选择。膳食补充剂被认为是传统疗法的一种有吸引力的替代方法，主要是因为普通人群都可以获得。本研究的目的是调查能量限制（ER）与四种膳食补充剂联合使用对100名超重或肥胖参与者人体测量和生化参数变化的附加作用，这些参与者被随机分配服用含有不同膳食纤维的膳食纤维补充剂或安慰剂，为期8周。结果证实，在研究开始后的第4周和第8周，膳食纤维补充剂加ER显著（<0.01）降低了体重、体重指数（BMI）、脂肪量和内脏脂肪，并改善了血脂水平和炎症，而在安慰剂组中，仅在ER 8周后才观察到一些参数的显著差异。含有魔芋、菊粉、车前子和苹果纤维的膳食纤维补充剂在降低BMI、体重和CRP方面最有效（干预结束时，与安慰剂相比，BMI和体重的P = 0.018，CRP的P = 0.034）。总体而言，结果表明膳食纤维补充剂与ER联合使用可能对体重减轻和代谢状况有额外影响。因此，服用膳食纤维补充剂可能是改善肥胖和超重个体体重及代谢健康的一种可行方法。
