Khossousi A, Binns C W, Dhaliwal S S, Pal S
Department of Nutrition, Dietetics and Food Science, ATN Centre for Metabolic Fitness, School of Public Health, Curtin University, Perth, WA, Australia.
Br J Nutr. 2008 May;99(5):1068-75. doi: 10.1017/S0007114507864804. Epub 2007 Nov 16.
Overweight and obesity is one of the risk factors for developing CVD. At present, very little is known about the acute effects of dietary fibre on lipids, glucose and insulin, resting energy expenditure and diet-induced thermogenesis in overweight and obese individuals. This study examined the postprandial metabolic effects of dietary fibre in overweight and obese men. Ten overweight and obese men consumed a mixed meal accompanied by either a high-fibre or low-fibre supplement on two separate visits, in a random order, 1 week apart. Two isoenergetic breakfast meals with similar composition were consumed by ten overweight/obese men. The meals contained either a low (3 g) or high (15 g) amount of fibre, low-fibre meal (LFM) and high-fibre meal (HFM) respectively. Analysis was carried out using paired t test and ANOVA. Serum TAG incremental area under the curve during 6 h of the postprandial period was significantly lower after the consumption of HFM compared with LFM. At the first hour of the postprandial period, plasma apo B48 concentration after consumption of HFM was significantly lower compared with LFM. The resting energy expenditure and diet-induced thermogenesis after both meals was similar during 6 h of the postprandial period. Collectively, these findings suggest that a single acute dose of dietary fibre in the form of psyllium supplement can decrease arterial exposure to TAG and modify chylomicron responses in the postprandial period.
超重和肥胖是心血管疾病（CVD）发病的危险因素之一。目前，关于膳食纤维对超重和肥胖个体的脂质、葡萄糖和胰岛素、静息能量消耗以及饮食诱导产热的急性影响，人们了解甚少。本研究考察了膳食纤维对超重和肥胖男性餐后代谢的影响。10名超重和肥胖男性在两次单独就诊时，以随机顺序、间隔1周分别食用一顿混合餐，并搭配高纤维或低纤维补充剂。10名超重/肥胖男性食用了两种能量相等、成分相似的早餐。这些餐食分别含有低量（3克）或高量（15克）的纤维，即低纤维餐（LFM）和高纤维餐（HFM）。采用配对t检验和方差分析进行分析。与低纤维餐相比，食用高纤维餐后6小时血清甘油三酯（TAG）曲线下增量面积显著降低。在餐后第1小时，食用高纤维餐后的血浆载脂蛋白B48浓度与低纤维餐相比显著降低。两餐之后的静息能量消耗和饮食诱导产热在餐后6小时相似。总体而言，这些发现表明以车前草补充剂形式的单一急性剂量膳食纤维可减少动脉对TAG的暴露，并在餐后改变乳糜微粒反应。
