Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
J Am Acad Dermatol. 2010 Nov;63(5):805-14. doi: 10.1016/j.jaad.2009.08.066. Epub 2010 Aug 21.
Nevus simplex (NS) is a common birthmark on the forehead, glabella, upper eyelids, and nape. More widespread involvement can be confused with port-wine stains (nevus flammeus) and other vascular birthmarks.
To further categorize the anatomic locations in infants with extensive NS and evaluate for any possible disease associations.
We conducted a retrospective review of patients with extensive NS seen at two tertiary care centers.
Twenty-seven patients with extensive NS were identified. All had at least one typical site of involvement: glabella (77.8%), nape (59.3%), and eyelids (55.6%). Additional sites were the scalp, including the vertex, occiput, parietal (66.7%); nose (66.7%); lip (59.2%); lumbosacral skin (55.6%); and upper and mid back (14.8 %).
Retrospective nature of the study and relatively small sample size.
We propose the term "nevus simplex complex" for NS with more widespread involvement beyond the typical sites. Consistent use of the term "nevus simplex" will aid in correct diagnosis and appropriate management of these birthmarks.
单纯性痣（NS）是一种常见的额部、眉间、上眼睑和颈后的胎记。更广泛的累及范围可能与葡萄酒色斑（焰色痣）和其他血管性胎记相混淆。
进一步对广泛累及的 NS 婴儿的解剖部位进行分类，并评估是否存在任何可能的疾病关联。
我们对在两个三级医疗中心就诊的广泛累及 NS 的患者进行了回顾性研究。
共确定了 27 例广泛累及 NS 的患者。所有患者均至少有一处典型受累部位：眉间（77.8%）、颈后（59.3%）和眼睑（55.6%）。其他受累部位包括头皮，包括头顶、枕骨、顶骨（66.7%）；鼻子（66.7%）；嘴唇（59.2%）；腰骶部皮肤（55.6%）；以及上背部和中背部（14.8%）。
研究为回顾性，样本量相对较小。
我们提出将更广泛累及超出典型部位的 NS 称为“单纯性痣复合体”。正确使用“单纯性痣”这一术语将有助于正确诊断和适当管理这些胎记。
