Research Laboratory for Stereology and Neuroscience, Bispebjerg University Hospital, Copenhagen, NV, Denmark.
Neurobiol Aging. 2012 Jan;33(1):197.e11-20. doi: 10.1016/j.neurobiolaging.2010.06.013. Epub 2010 Aug 21.
Nonquantitative studies indicate that the cerebellum is neuropathologically affected in Alzheimer's disease; however, no quantitative studies on the subject have yet been conducted. Ten cerebella from elderly female subjects with severe Alzheimer's disease and 10 age- and gender-matched controls were examined. The cerebellum was divided into 5 regions and the Purkinje and granule cell number and density, cortical volume, molecular and granular layer volume and thickness, white matter volume, surface area, and the Purkinje cell gradient were stereologically estimated. There was no significant difference between the groups in Purkinje or granule cell number or density, and no overall difference in Purkinje cell gradient. However, there was a significant 12.7% reduction in total cerebellar volume in the Alzheimer's group and significant localized differences between the groups regarding other parameters. The relative lack of neuropathological changes in the cerebellum of severely demented Alzheimer's patients suggests that neuronal cell bodies on a global scale apparently still are intact.
非定量研究表明，小脑在阿尔茨海默病中存在神经病理学改变；然而，目前尚未对此进行定量研究。本研究对 10 例患有严重阿尔茨海默病的老年女性患者和 10 例年龄和性别匹配的对照组的小脑进行了研究。将小脑分为 5 个区域，采用体视学方法对浦肯野细胞和颗粒细胞数量和密度、皮质体积、分子层和颗粒层体积和厚度、白质体积、表面积以及浦肯野细胞梯度进行了评估。两组之间浦肯野细胞或颗粒细胞数量或密度无显著差异，浦肯野细胞梯度也无总体差异。然而，阿尔茨海默病组的总小脑体积显著减少了 12.7%，且两组间其他参数存在显著的局部差异。严重痴呆的阿尔茨海默病患者小脑神经病理学改变相对较少，提示小脑神经元胞体在全球范围内仍明显完整。
