Department of Biology, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA.
Mech Ageing Dev. 2010 Sep;131(9):580-3. doi: 10.1016/j.mad.2010.08.003. Epub 2010 Aug 20.
Aging is associated with a decreased CD8 T cell response to multiple antigens and to virus infection. Although both intrinsic and extrinsic factors have been shown to contribute to the decrease, the mechanisms are still largely unknown. In this study, the role of dendritic cells (DCs) in the age-associated decrease was examined. Influenza-specific TCR transgenic CD8 T cells of young mice demonstrated limited expansion in response to influenza infection when adoptively transferred to aged compared to young mice. This decreased response in aged mice could be significantly enhanced when DCs of young mice were co-transferred. Co-transfer of DCs had no impact in young recipient mice. Adoptive transfer of the DCs also increased the endogenous CD8 T cell response of intact aged mice, although to a lesser degree. These results suggest that the diminished CD8 T cell response to virus infection in aged mice is partially attributable to age-associated changes in DCs.
衰老是与对多种抗原和病毒感染的 CD8 T 细胞反应能力下降相关的。尽管已经表明内在和外在因素都有助于这种下降，但机制仍在很大程度上未知。在这项研究中，研究了树突状细胞（DC）在与年龄相关的下降中的作用。当从年轻小鼠中过继转移到老年小鼠中时，针对流感的特异性 TCR 转基因 CD8 T 细胞对流感感染的反应显示出有限的扩增。当共转移年轻小鼠的 DC 时，老年小鼠中这种反应的减少可以显著增强。共转移 DC 对年轻受者小鼠没有影响。DC 的过继转移也增加了完整老年小鼠的内源性 CD8 T 细胞反应，尽管程度较小。这些结果表明，老年小鼠对病毒感染的 CD8 T 细胞反应减弱部分归因于 DC 与年龄相关的变化。
