Laboratorio de Zoología de Invertebrados II, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan 670, 8000 Bahía Blanca, Argentina.
J Ethnopharmacol. 2010 Oct 28;132(1):321-7. doi: 10.1016/j.jep.2010.08.035. Epub 2010 Aug 20.
Several extracts of Schinus molle var. areira L. plant proved to be useful for the treatment of different pathologies and for the control of insect pest. Due to these potential uses, it is necessary to study their safety. In this work, we evaluated the effects of subchronic exposure to ethanolic extracts from leaves and fruits of Schinus molle var. areira in mice.
The plant extract was added to the diet at 1 g/kg body weight/day for 90 days. At the end of the exposure, behavioral and functional parameters in a functional observational battery and motor activity in an open field were assessed. Finally, several biochemical and histopathological studies were realized.
The exposure to extract from leaves produced an increase in the number of rearings in the open field and of urine pools in the functional observational battery. On the other hand, the exposure to extract from fruits produced an increase in the neutrophil count and a decrease in the lymphocyte count and in the total cholesterol levels. None of the exposures affected the different organs evaluated.
Our results suggest that subchronic exposure to ethanolic extracts from leaves and fruits of Schinus molle var. areira should be potentially useful in the treatment of lipid pathologies and safe to use.
几种 Schinus molle var. areira L. 植物提取物已被证明可用于治疗多种疾病和防治害虫。鉴于这些潜在用途，有必要对其安全性进行研究。在这项工作中，我们评估了亚慢性暴露于 Schinus molle var. areira 的叶和果实的乙醇提取物对小鼠的影响。
将植物提取物以 1 g/kg 体重/天的剂量添加到饮食中，持续 90 天。在暴露结束时，在功能观察电池中评估行为和功能参数，在开放场中评估运动活动。最后，进行了多项生化和组织病理学研究。
暴露于叶提取物会增加开放场中的后肢支撑次数和功能观察电池中的尿液池数量。另一方面，暴露于果实提取物会增加中性粒细胞计数，减少淋巴细胞计数和总胆固醇水平。所有暴露均未影响评估的不同器官。
我们的结果表明，亚慢性暴露于 Schinus molle var. areira 的叶和果实的乙醇提取物可能对治疗脂质疾病有用且安全。
