Department of Chemistry and Institute of Nanochemistry, Jinan University, 601 Huangpudadaoxi Road, Guangzhou 510632, PR China.
Colloids Surf B Biointerfaces. 2010 Dec 1;81(2):537-43. doi: 10.1016/j.colsurfb.2010.07.054. Epub 2010 Jul 30.
A simple, low cost and convenient method was used to prepare SiO2@Cu core-shell composite using SiO2 spheres as the core and copper nanoparticles as the shell. A uniform spherical particle of SiO2 was fabricated according to an improved Stöber method. The SiO2 spheres served as a support for the immobilization of copper by reducing Cu2+ in aqueous solution using Fe power. The chemical structures and morphologies of the SiO2 and SiO2@Cu composite were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). E. coli (Escherichia coli), S. aureus (Staphylococcus aureus) and C. albicans (Candida albicans) were utilized to test its antibacterial effect. Results of XRD, TEM and XPS demonstrated that the copper nanoparticles shell supported on the surface of SiO2 spheres. With regard to the antibacterial effect, E. coli was more easily killed than S. aureus and C. albicans after 24 h incubation, and the pictures of TEM showed obviously morphological changes of the antibacterial activity. The results demonstrated that Cu supported on the surface of SiO2 spheres without aggregation, which was proved to be a good novel antibacterial material.
一种简单、低成本且方便的方法被用于制备以 SiO2 球为核、铜纳米粒子为壳的 SiO2@Cu 核壳复合材料。采用改进的 Stöber 法制备了均匀的 SiO2 球形颗粒。SiO2 球作为载体，通过 Fe 粉将水溶液中的 Cu2+还原，从而实现铜的固定。通过 X 射线衍射（XRD）、透射电子显微镜（TEM）和 X 射线光电子能谱（XPS）对 SiO2 和 SiO2@Cu 复合材料的化学结构和形态进行了表征。采用大肠杆菌（Escherichia coli）、金黄色葡萄球菌（Staphylococcus aureus）和白色念珠菌（Candida albicans）来测试其抗菌效果。XRD、TEM 和 XPS 的结果表明，铜纳米粒子壳支撑在 SiO2 球的表面上。关于抗菌效果，在孵育 24 小时后，大肠杆菌比金黄色葡萄球菌和白色念珠菌更容易被杀死，并且 TEM 的图片显示出明显的形态变化，具有抗菌活性。结果表明，Cu 负载在 SiO2 球表面上没有聚集，这被证明是一种良好的新型抗菌材料。
