Programa de Pós-graduação em Biologia Celular e Estrutural, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), CP 6109, 13083-970 Campinas, SP, Brazil.
Bioorg Med Chem. 2010 Sep 15;18(18):6742-7. doi: 10.1016/j.bmc.2010.07.053. Epub 2010 Jul 27.
In this work the antiproliferative activity of goniothalamin (1), both in racemic and in its enantiomeric pure forms, in a solid tumor experimental model using laboratory animals is described. The antiedematogenic activity displayed by racemic 1 in the carrageenan edema model in mice together with the reduction of Ehrlich solid tumor model suggest a relationship between anticancer and antiinflammatory activities with the antiinflammatory activity favoring the antiproliferative activity itself.
在这项工作中，描述了戈尼辛（1）在使用实验动物的实体瘤实验模型中的抗增殖活性，无论是外消旋体还是其对映体纯形式。外消旋 1 在小鼠角叉菜胶水肿模型中表现出的抗水肿活性以及对艾氏腹水癌模型的抑制作用提示抗癌和抗炎活性之间存在关系，抗炎活性有利于抗增殖活性本身。
