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调控酵母交配型基因和哺乳动物主要组织相容性复合体基因的机制之间存在惊人的相似性。

Striking similarities between the regulatory mechanisms governing yeast mating-type genes and mammalian major histocompatibility complex genes.

作者信息

Weissman J D, Singer D S

机构信息

Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland 20892.

出版信息

Mol Cell Biol. 1991 Aug;11(8):4228-34. doi: 10.1128/mcb.11.8.4228-4234.1991.

DOI:10.1128/mcb.11.8.4228-4234.1991
PMID:2072916
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC361249/
Abstract

Expression of a mammalian major histocompatibility complex (MHC) class I gene is in part regulated by a silencer DNA sequence element which binds a complex of silencer factors. This negative regulatory system is shown to be strikingly similar to the yeast alpha 2 mating-type repression system. A moderate DNA sequence homology exists between the MHC class I silencer DNA element and the yeast alpha 2 operator. Mammalian silencer factors specifically bind to the yeast alpha 2 operator DNA and also specifically interact with a yeast alpha 2-binding protein. Furthermore, the alpha 2 operator functions as a silencer element in mammalian cells when placed upstream of a MHC class I promoter.

摘要

哺乳动物主要组织相容性复合体（MHC）I类基因的表达部分受一个沉默子DNA序列元件调控，该元件可结合沉默子因子复合体。现已表明，这种负调控系统与酵母α2交配型抑制系统惊人地相似。MHC I类沉默子DNA元件与酵母α2操纵基因之间存在一定程度的DNA序列同源性。哺乳动物沉默子因子能特异性结合酵母α2操纵基因DNA，还能与一种酵母α2结合蛋白特异性相互作用。此外，当置于MHC I类启动子上游时，α2操纵基因在哺乳动物细胞中可作为沉默子元件发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de51/361249/54569e13af03/molcellb00032-0418-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de51/361249/889c544252fa/molcellb00032-0416-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de51/361249/34df6fb539cd/molcellb00032-0417-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de51/361249/bbbb823faf43/molcellb00032-0417-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de51/361249/54569e13af03/molcellb00032-0418-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de51/361249/889c544252fa/molcellb00032-0416-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de51/361249/34df6fb539cd/molcellb00032-0417-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de51/361249/bbbb823faf43/molcellb00032-0417-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de51/361249/54569e13af03/molcellb00032-0418-a.jpg

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本文引用的文献

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