Department of Genetics, Faculty of Medicine, Valencia University, Spain.
J Dev Behav Pediatr. 2010 Sep;31(7):545-54. doi: 10.1097/DBP.0b013e3181ee4072.
The aims of this study were to review studies on the molecular genetics of child temperament and prospectively analyze infant temperament as a function of the interaction between infant and mother: 5-HTT, DRD4, and MAO-A functional polymorphisms and the mother's emotional state.
A prospective study of 317 newborns and their mothers was performed. Infant temperament and the mother's anxiety and confidence in caregiving were evaluated at 8 and 32 weeks after childbirth using the Mother and Baby Scale. The mother's emotional state was evaluated using the Edinburgh Postpartum Depression Scale and the State-Trait Anxiety Inventory. These variables were correlated with 5-HTTLPR and Stin2 variants in the 5-HTT gene and the DRD4 variable number tandem repeats Exon 3 and MAO-A variable number tandem repeats genotypes of both the infants and their mothers.
The irritability scores of infants with the 5-HTTLPR s allele showed a linear relationship with their mothers' anxiety of caregiving at 8 (p = .011) and 32 weeks (p = .001), whereas the irritability of infants carrying the HTTLPR ll genotype was independent of their mothers' anxiety.
The review of the literature in this field and the results of this study support that the 5-HTTLPR polymorphism moderates the influence of the mother's anxiety on infant irritability.
本研究旨在综述儿童气质的分子遗传学研究，并前瞻性分析婴儿气质与母婴相互作用的关系：5-HTT、DRD4 和 MAO-A 功能多态性以及母亲的情绪状态。
对 317 名新生儿及其母亲进行前瞻性研究。采用母婴量表（Mother and Baby Scale）在产后 8 周和 32 周评估婴儿气质和母亲的焦虑感和育儿信心。采用爱丁堡产后抑郁量表（Edinburgh Postpartum Depression Scale）和状态-特质焦虑量表（State-Trait Anxiety Inventory）评估母亲的情绪状态。将这些变量与婴儿和母亲的 5-HTT 基因中的 5-HTTLPR 和 Stin2 变异、DRD4 可变数串联重复 3 号外显子和 MAO-A 可变数串联重复多态性相关联。
携带 5-HTTLPR s 等位基因的婴儿的易激惹评分与其母亲在产后 8 周（p =.011）和 32 周（p =.001）时的育儿焦虑呈线性关系，而携带 HTTLPR ll 基因型的婴儿的易激惹则与其母亲的焦虑无关。
对该领域文献的综述和本研究的结果表明，5-HTTLPR 多态性调节了母亲的焦虑对婴儿易激惹的影响。
