Ibrahim Sherrif F, Brown Marc D
University of Rochester School of Medicine and Dentistry, Department of Dermatology, Rochester, New York.
J Clin Aesthet Dermatol. 2009 Jul;2(7):43-8.
Actinic keratoses are common intra-epidermal neoplasms that lie on a continuum with squamous cell carcinoma. Tightly linked to ultraviolet irradiation, they occur in areas of chronic sun exposure, and early treatment of these lesions may prevent their progression to invasive disease. A large variety of effective treatment modalities exist, and the optimal therapeutic choice is dependent on a variety of patient- and physician-associated variables. Many established and more recent approaches are discussed in this review with a focus on efficacy and administration techniques. Several previously experimental options, such as imiquimod and photodynamic therapy, have become incorporated as first-line options for the treatment of actinic keratoses, while combination treatment strategies have been gaining in popularity. The goal of all therapies is to ultimately limit the morbidity and mortality of squamous cell carcinoma. (J Clin Aesthetic Dermatol. 2009;2(7):43-48.).
光化性角化病是常见的表皮内肿瘤，与鳞状细胞癌处于连续谱中。它们与紫外线照射密切相关，发生于慢性阳光暴露部位，早期治疗这些病变可预防其进展为侵袭性疾病。存在多种有效的治疗方式，最佳治疗选择取决于多种患者和医生相关变量。本综述讨论了许多已确立的和最新的方法，重点是疗效和给药技术。几种先前的实验性选择，如咪喹莫特和光动力疗法，已成为治疗光化性角化病的一线选择，而联合治疗策略也越来越受欢迎。所有治疗的目标最终都是限制鳞状细胞癌的发病率和死亡率。（《临床美容皮肤病学杂志》。2009年；2(7):43 - 48。）
